Evaluation of the efficacy of Lawsonia alba in the alleviation of carbon tetrachloride-induced oxidative stress

S. Ahmed, A. Rahman, A. Alam, M. Saleem, M. Athar, S. Sultana

Research output: Contribution to journalArticlepeer-review

78 Scopus citations

Abstract

The hepatoprotective activity of the 50% ethanol extract of the bark of Lawsonia alba syn. L. inermis was investigated against the carbon tetrachloride-induced oxidative stress. Pretreatment of rats with doses of 250 and 500 mg/kg of the plant extract significantly (P<0.001) lowered serum transaminases (GOT and GPT) and LDH levels, respectively, in a dose dependent manner against the significant (P<0.001) rise of these damage marker enzymes when challenged with CCl4 (1 ml/kg, orally). Parallel to these changes, the plant extract prevented CCl4-induced oxidative stress by significantly maintaining the levels of reduced glutathione (GSH), its metabolizing enzymes and simultaneously inhibiting the production of free radicals. Pretreatment of rats with the extract also inhibited the peroxidation of microsomal lipids in a dose-dependent manner.

Original languageEnglish (US)
Pages (from-to)157-164
Number of pages8
JournalJournal of Ethnopharmacology
Volume69
Issue number2
DOIs
StatePublished - Feb 2000
Externally publishedYes

Keywords

  • Carbon tetrachloride
  • Hepatoprotective
  • Lawsonia alba
  • Lipid peroxidation
  • Oxidative stress

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