TY - JOUR
T1 - Evidence for specificity of ERP abnormalities during response inhibition in ADHD children
T2 - A comparison with reading disorder children without ADHD
AU - Liotti, Mario
AU - Pliszka, Steven R.
AU - Higgins, Kellie
AU - Perez, Ricardo
AU - Semrud-Clikeman, Margaret
PY - 2010/3
Y1 - 2010/3
N2 - Executive function and working memory deficits are not only present in ADHD, but also in reading disorder (RD). Here, high-density ERPs were recorded during the Stop Signal Task in 53 children and adolescents: An ADHD-combined type group, a group with RD, and a healthy control group. The ADHD-C group displayed unique abnormalities of the frontal N200. Both healthy controls and RD groups showed a success-related right frontal N200 modulation, which was absent in the ADHD group. Second, for Success Inhibition trials, the ADHD-C had smaller right frontal N200 waves relative to healthy controls, while the RD group did not. In contrast, NoGo-P3 abnormalities were present both in the ADHD-C and RD groups. Impaired early response inhibition mechanisms, indexed by the frontal N200, appear to be limited to ADHD-C. In contrast, deficits in later cognitive control and error monitoring mechanisms, indexed by the NoGo-P3, appear to be present in both conditions.
AB - Executive function and working memory deficits are not only present in ADHD, but also in reading disorder (RD). Here, high-density ERPs were recorded during the Stop Signal Task in 53 children and adolescents: An ADHD-combined type group, a group with RD, and a healthy control group. The ADHD-C group displayed unique abnormalities of the frontal N200. Both healthy controls and RD groups showed a success-related right frontal N200 modulation, which was absent in the ADHD group. Second, for Success Inhibition trials, the ADHD-C had smaller right frontal N200 waves relative to healthy controls, while the RD group did not. In contrast, NoGo-P3 abnormalities were present both in the ADHD-C and RD groups. Impaired early response inhibition mechanisms, indexed by the frontal N200, appear to be limited to ADHD-C. In contrast, deficits in later cognitive control and error monitoring mechanisms, indexed by the NoGo-P3, appear to be present in both conditions.
KW - ADHD
KW - Event-related potentials
KW - Inhibitory control
KW - N200
KW - NoGo-P3
KW - Reading disorder
KW - Stop Signal Task
UR - http://www.scopus.com/inward/record.url?scp=75149149001&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=75149149001&partnerID=8YFLogxK
U2 - 10.1016/j.bandc.2009.09.007
DO - 10.1016/j.bandc.2009.09.007
M3 - Article
C2 - 19850394
AN - SCOPUS:75149149001
SN - 0278-2626
VL - 72
SP - 228
EP - 237
JO - Brain and Cognition
JF - Brain and Cognition
IS - 2
ER -