Evidence for two independent distributions of serum immunoglobulin e in atopic families: Cognate and non-cognate IgE

Duaine R. Jackola; Malcolm N Blumenthal; Andreas Rosenberg

doi:10.1016/j.humimm.2003.10.012

Evidence for two independent distributions of serum immunoglobulin e in atopic families: Cognate and non-cognate IgE

Duaine R. Jackola, Malcolm N Blumenthal, Andreas Rosenberg

Medicine - Pulmonary, Allergy, Critical

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Genetic studies of IgE-mediated atopic disease have produced conflicting results, due largely to variable phenotype definitions. Total IgE concentrations and 14 allergen skin prick tests (SPT) were determined in 1099 members of families with history of atopy. Log₁₀ [Total IgE] values were normally distributed in both atopic (SPT [+]) and non-atopic (SPT [-]) groups. The mean Log₁₀ [Total IgE] value was higher in the atopic group, although the standard deviations of the distributions were the same. The mean Log₁₀ [Total IgE] value of the non-atopic distribution was subtracted from the individual Log₁₀ [Total IgE] values of the atopic group giving an allergen-specific fraction. There was a strong positive correlation between the specific IgE fraction and the number (#) SPT [+] results, defined as Cognate IgE. Among the atopics, subtracting the Cognate IgE value from total IgE yielded Non-Cognate IgE. The Cognate and Non-Cognate IgE distributions were statistically uncorrelated. Evidence is presented for two serum IgE fractions that are statistically and physiologically independent of one another in atopic families; a Cognate IgE fraction associated with atopic sensitization and a Non-Cognate IgE fraction unrelated to atopic disease. Elevated serum IgE is a consequence, not a predisposing cause, of allergen sensitization.

Original language	English (US)
Pages (from-to)	20-30
Number of pages	11
Journal	Human Immunology
Volume	65
Issue number	1
DOIs	https://doi.org/10.1016/j.humimm.2003.10.012
State	Published - Jan 2004

Bibliographical note

Funding Information:
Supported by N.I.H. grant 2 RO1-HL049609-11 and the Asthma and Allergy Research Fund, Department of Medicine, University of Minnesota. This is manuscript MSP-007-2003 of the Asthma and Allergy Center, University of Minnesota Medical School.

Keywords

Allergy
Atopy
IgE

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title = "Evidence for two independent distributions of serum immunoglobulin e in atopic families: Cognate and non-cognate IgE",

abstract = "Genetic studies of IgE-mediated atopic disease have produced conflicting results, due largely to variable phenotype definitions. Total IgE concentrations and 14 allergen skin prick tests (SPT) were determined in 1099 members of families with history of atopy. Log10 [Total IgE] values were normally distributed in both atopic (SPT [+]) and non-atopic (SPT [-]) groups. The mean Log10 [Total IgE] value was higher in the atopic group, although the standard deviations of the distributions were the same. The mean Log10 [Total IgE] value of the non-atopic distribution was subtracted from the individual Log10 [Total IgE] values of the atopic group giving an allergen-specific fraction. There was a strong positive correlation between the specific IgE fraction and the number (#) SPT [+] results, defined as Cognate IgE. Among the atopics, subtracting the Cognate IgE value from total IgE yielded Non-Cognate IgE. The Cognate and Non-Cognate IgE distributions were statistically uncorrelated. Evidence is presented for two serum IgE fractions that are statistically and physiologically independent of one another in atopic families; a Cognate IgE fraction associated with atopic sensitization and a Non-Cognate IgE fraction unrelated to atopic disease. Elevated serum IgE is a consequence, not a predisposing cause, of allergen sensitization.",

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Evidence for two independent distributions of serum immunoglobulin e in atopic families: Cognate and non-cognate IgE

Abstract

Bibliographical note

Keywords

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