Executive function: Responses to aerobic exercise in Alzheimer's disease

Fang Yu; David M. Vock; Terry R. Barclay

doi:10.1016/j.gerinurse.2017.09.005

Executive function: Responses to aerobic exercise in Alzheimer's disease

Fang Yu, David M. Vock, Terry R. Barclay

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Executive dysfunction occurs early and is prevalent in Alzheimer's disease (AD). This study tested the ability of different measures for identifying changes in executive function and the effect of 6-months of aerobic exercise on executive function in older adults with mild to moderate AD, using a single-group, repeated-measures design (n = 28, age 78.1 ± 8.37). Factor analysis and linear mixed-effects model analyses showed that individually the Exit Interview-25 (EXIT-25), Behavioral Dyscontrol Scale (BDS), and Golden Stroop test were the preferred instruments for measuring changes in executive function in the sample. The COWAT and TMT had substantial floor effects limiting their ability to identify changes in executive function. A single latent factor was sufficient to describe the heterogeneity of executive function. Over 6 months, aerobic exercise maintained executive function (effect size = −0.11, −0.24, −0.27, and −0.21 for the EXIT-25, BDS, Stroop, and latent factor, respectively). Decline in the latent factor (effect size = −0.21, p = 0.06) was minimal and comparable to that in global cognition (effect size = −0.20, p = 0.34). Aerobic exercise may be effective on maintaining executive function in AD.

Original language	English (US)
Pages (from-to)	219-224
Number of pages	6
Journal	Geriatric Nursing
Volume	39
Issue number	2
DOIs	https://doi.org/10.1016/j.gerinurse.2017.09.005
State	Published - Mar 1 2018

Bibliographical note

Funding Information:
The design and implementation of the study was funded by the National Institute of Health K12 Career Advancement Award ( RR023247-04 ) and BrightFocus ® Foundation ( A2009344 ). The data analysis and manuscript preparation were supported by the National Institute on Aging of the National Institutes of Health Award Number R01AG043392-01A1 . All subject interviews and data collections occurred at the CTSI that was supported by the National Institutes of Health National Center for Advancing Translational Sciences of the National Institutes of Health Award Number UL1TR000114 . The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Publisher Copyright:
© 2017 Elsevier Inc.

Keywords

Aging
Alzheimer's disease
Cognition
Executive function
Exercise

Access

10.1016/j.gerinurse.2017.09.005

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897173

OpenUrl availability

Full text

Cite this

@article{a4656419cbcf4970844bf22de77cf4b2,

title = "Executive function: Responses to aerobic exercise in Alzheimer's disease",

abstract = "Executive dysfunction occurs early and is prevalent in Alzheimer's disease (AD). This study tested the ability of different measures for identifying changes in executive function and the effect of 6-months of aerobic exercise on executive function in older adults with mild to moderate AD, using a single-group, repeated-measures design (n = 28, age 78.1 ± 8.37). Factor analysis and linear mixed-effects model analyses showed that individually the Exit Interview-25 (EXIT-25), Behavioral Dyscontrol Scale (BDS), and Golden Stroop test were the preferred instruments for measuring changes in executive function in the sample. The COWAT and TMT had substantial floor effects limiting their ability to identify changes in executive function. A single latent factor was sufficient to describe the heterogeneity of executive function. Over 6 months, aerobic exercise maintained executive function (effect size = −0.11, −0.24, −0.27, and −0.21 for the EXIT-25, BDS, Stroop, and latent factor, respectively). Decline in the latent factor (effect size = −0.21, p = 0.06) was minimal and comparable to that in global cognition (effect size = −0.20, p = 0.34). Aerobic exercise may be effective on maintaining executive function in AD.",

keywords = "Aging, Alzheimer's disease, Cognition, Executive function, Exercise",

author = "Fang Yu and Vock, {David M.} and Barclay, {Terry R.}",

note = "Funding Information: The design and implementation of the study was funded by the National Institute of Health K12 Career Advancement Award ( RR023247-04 ) and BrightFocus {\textregistered} Foundation ( A2009344 ). The data analysis and manuscript preparation were supported by the National Institute on Aging of the National Institutes of Health Award Number R01AG043392-01A1 . All subject interviews and data collections occurred at the CTSI that was supported by the National Institutes of Health National Center for Advancing Translational Sciences of the National Institutes of Health Award Number UL1TR000114 . The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

year = "2018",

month = mar,

day = "1",

doi = "10.1016/j.gerinurse.2017.09.005",

language = "English (US)",

volume = "39",

pages = "219--224",

journal = "Geriatric Nursing",

issn = "0197-4572",

publisher = "Mosby Inc.",

number = "2",

}

TY - JOUR

T1 - Executive function

T2 - Responses to aerobic exercise in Alzheimer's disease

AU - Yu, Fang

AU - Vock, David M.

AU - Barclay, Terry R.

N1 - Funding Information: The design and implementation of the study was funded by the National Institute of Health K12 Career Advancement Award ( RR023247-04 ) and BrightFocus ® Foundation ( A2009344 ). The data analysis and manuscript preparation were supported by the National Institute on Aging of the National Institutes of Health Award Number R01AG043392-01A1 . All subject interviews and data collections occurred at the CTSI that was supported by the National Institutes of Health National Center for Advancing Translational Sciences of the National Institutes of Health Award Number UL1TR000114 . The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: © 2017 Elsevier Inc.

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Executive dysfunction occurs early and is prevalent in Alzheimer's disease (AD). This study tested the ability of different measures for identifying changes in executive function and the effect of 6-months of aerobic exercise on executive function in older adults with mild to moderate AD, using a single-group, repeated-measures design (n = 28, age 78.1 ± 8.37). Factor analysis and linear mixed-effects model analyses showed that individually the Exit Interview-25 (EXIT-25), Behavioral Dyscontrol Scale (BDS), and Golden Stroop test were the preferred instruments for measuring changes in executive function in the sample. The COWAT and TMT had substantial floor effects limiting their ability to identify changes in executive function. A single latent factor was sufficient to describe the heterogeneity of executive function. Over 6 months, aerobic exercise maintained executive function (effect size = −0.11, −0.24, −0.27, and −0.21 for the EXIT-25, BDS, Stroop, and latent factor, respectively). Decline in the latent factor (effect size = −0.21, p = 0.06) was minimal and comparable to that in global cognition (effect size = −0.20, p = 0.34). Aerobic exercise may be effective on maintaining executive function in AD.

AB - Executive dysfunction occurs early and is prevalent in Alzheimer's disease (AD). This study tested the ability of different measures for identifying changes in executive function and the effect of 6-months of aerobic exercise on executive function in older adults with mild to moderate AD, using a single-group, repeated-measures design (n = 28, age 78.1 ± 8.37). Factor analysis and linear mixed-effects model analyses showed that individually the Exit Interview-25 (EXIT-25), Behavioral Dyscontrol Scale (BDS), and Golden Stroop test were the preferred instruments for measuring changes in executive function in the sample. The COWAT and TMT had substantial floor effects limiting their ability to identify changes in executive function. A single latent factor was sufficient to describe the heterogeneity of executive function. Over 6 months, aerobic exercise maintained executive function (effect size = −0.11, −0.24, −0.27, and −0.21 for the EXIT-25, BDS, Stroop, and latent factor, respectively). Decline in the latent factor (effect size = −0.21, p = 0.06) was minimal and comparable to that in global cognition (effect size = −0.20, p = 0.34). Aerobic exercise may be effective on maintaining executive function in AD.

KW - Aging

KW - Alzheimer's disease

KW - Cognition

KW - Executive function

KW - Exercise

UR - http://www.scopus.com/inward/record.url?scp=85031117383&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85031117383&partnerID=8YFLogxK

U2 - 10.1016/j.gerinurse.2017.09.005

DO - 10.1016/j.gerinurse.2017.09.005

M3 - Article

C2 - 29031520

AN - SCOPUS:85031117383

SN - 0197-4572

VL - 39

SP - 219

EP - 224

JO - Geriatric Nursing

JF - Geriatric Nursing

IS - 2

ER -

Executive function: Responses to aerobic exercise in Alzheimer's disease

Abstract

Bibliographical note

Keywords

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this