Abstract
Hormesis plays a critical role in producing some major benefits derived from physical exercise. However whether these known cellular mechanisms are applicable to ameliorate age-related deterioration of muscle function is not entirely clear. The present communication proposes that antioxidant adaptation, the peroxisome proliferator-activated receptor gamma coactivator (PGC)-1α activated mitochondrial biogenesis, and eccentric contraction-induced, cytokine-propelled muscle inflammation could be important redox-sensitive pathways by which exercise-induced disturbance in oxidant-antioxidant hemeostasis may serve as a heretic stimulus to promote adaptations that help healthy aging and improve the quality of life.
Original language | English (US) |
---|---|
Pages (from-to) | 73-79 |
Number of pages | 7 |
Journal | Dose-Response |
Volume | 8 |
Issue number | 1 |
DOIs | |
State | Published - 2010 |
Externally published | Yes |
Keywords
- Aging
- Exercise
- Hormesis
- Muscle
- Reactive oxygen species