Exercise Intolerance in Heart Failure: Central Role for the Pulmonary System

Sophie Lalande, Troy J. Cross, Manda L. Keller-Ross, Norman R. Morris, Bruce D. Johnson, Bryan J. Taylor

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


We propose that abnormalities of the pulmonary system contribute significantly to the exertional dyspnea and exercise intolerance observed in patients with chronic heart failure. Interventions designed to address the deleterious pulmonary manifestations of heart failure may, therefore, yield promising improvements in exercise tolerance in this population.

Original languageEnglish (US)
Pages (from-to)11-19
Number of pages9
JournalExercise and sport sciences reviews
Issue number1
StatePublished - Jan 1 2020

Bibliographical note

Funding Information:
This study was supported by National Instituted of Health (NIH) grant HL071478. Bryan J. Taylor and Sophie Lalande were supported by the American Heart Association Postdoctoral Fellowships (12POST12070084 and 0920054G, respectively). Troy J. Cross was supported by an Australian Post-graduate Award. Manda L. Keller-Ross was supported by an NIH/NIAMS T32AR56950 grant.


  • bronchial vasculature
  • exercise tolerance
  • heart failure
  • intrathoracic pressure
  • pulmonary hypertension
  • ventilatory inefficiency
  • work of breathing

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