Expanding roles of superoxide dismutases in cell regulation and cancer

Meixia Che, Ren Wang, Xiaoxing Li, Hui Yun Wang, X. F.Steven Zheng

Research output: Contribution to journalReview articlepeer-review

89 Scopus citations

Abstract

Reactive oxygen species (ROS) have important roles in normal physiology and diseases, particularly cancer. Under normal physiological conditions, they participate in redox reactions and serve as second messengers for regulatory functions. Owing to aberrant metabolism, cancer cells accumulate excessive ROS, thus requiring a robustly active antioxidant system to prevent cellular damage. Superoxide dismutases (SODs) are enzymes that catalyze the removal of superoxide free radicals. There are three distinct members of this metalloenzyme family in mammals: SOD1 (Cu/ZnSOD), SOD2 (MnSOD) and SOD3 (ecSOD). SODs are increasingly recognized for their regulatory functions in growth, metabolism and oxidative stress responses, which are also crucial for cancer development and survival. Growing evidence shows that SODs are also potentially useful anticancer drug targets. This review will focus on recent research of SODs in cellular regulation, with emphasis on their roles in cancer biology and therapy.

Original languageEnglish (US)
Pages (from-to)143-149
Number of pages7
JournalDrug Discovery Today
Volume21
Issue number1
DOIs
StatePublished - Jan 1 2016

Bibliographical note

Funding Information:
The work is supported by NIH R01 grants CA123391 , CA166575 and CA173519 (X.F.Z.).

Publisher Copyright:
© 2015 Elsevier Ltd. All rights reserved.

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