Expedient synthesis of long-chain ω-substituted fatty acids and esters from cyclic ketones using iodine and hydrogen peroxide

Ekaterina V. Podrezova, Maria S. Larkina, Mikhail V. Belousov, Andreas Kirschning, Viktor V. Zhdankin, Mekhman S. Yusubov

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

A simple and convenient synthesis of ω-iodoaliphatic carboxylic acids and esters by the reaction of cyclic ketones with iodine and hydrogen peroxide in the presence of catalytic CuCl has been developed. ω-Iodoaliphatic carboxylic esters were further used for the efficient preparation of di(2-pyridylmethylamino)alkanoic acids in excellent yields.

Original languageEnglish (US)
Pages (from-to)4081-4088
Number of pages8
JournalSynthesis (Germany)
Volume50
Issue number20
DOIs
StatePublished - 2018

Keywords

  • chelating reagents
  • cyclic ketones
  • di-(2-picolyl)amine
  • di-(2-pyridylmethylamino)alkanoic acids
  • ligands
  • ω-iodo-aliphatic carboxylic esters
  • ω-iodoaliphatic carboxylic acids

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