A simple and convenient synthesis of ω-iodoaliphatic carboxylic acids and esters by the reaction of cyclic ketones with iodine and hydrogen peroxide in the presence of catalytic CuCl has been developed. ω-Iodoaliphatic carboxylic esters were further used for the efficient preparation of di(2-pyridylmethylamino)alkanoic acids in excellent yields.
- chelating reagents
- cyclic ketones
- di-(2-pyridylmethylamino)alkanoic acids
- ω-iodo-aliphatic carboxylic esters
- ω-iodoaliphatic carboxylic acids