Abstract
Methods of creating experimental complete heart block developed since 1883 are reviewed in detail. The three most commonly used techniques at present are: (I) Thoracotomy, atriotomy and ligation of the A-V bundle. (II) Thoracotomy and injection of a chemical into the A-V node or bundle. (III) Injection of a chemical through a transvenous catheter into the node or bundle. The results in different species, complications, and variations in procedure are discussed. The bibliography provides a comprehensive index of work performed in animals with experimental complete heart block. We produced complete heart block in sixteen pigs but subsequently elven died during Stokes-Adams attacks. Pigs have not been used previously as models of heart block for experimental purposes and prophylactic pacing appears mandatory in this species.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 446-455 |
| Number of pages | 10 |
| Journal | Basic research in cardiology |
| Volume | 70 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jul 1975 |
| Externally published | Yes |