Exploring whole-genome duplicate gene retention with complex genetic interaction analysis

Elena Kuzmin; Benjamin J VanderSluis; Alex N.Nguyen Ba; Wen Wang; Elizabeth N. Koch; Matej Usaj; Anton Khmelinskii; Mojca Mattiazzi Usaj; Jolanda Van Leeuwen; Oren Kraus; Amy Tresenrider; Michael Pryszlak; Ming Che Hu; Brenda Varriano; Michael Costanzo; Michael Knop; Alan Moses; Chad L. Myers; Brenda J. Andrews; Charles Boone

doi:10.1126/science.aaz5667

Exploring whole-genome duplicate gene retention with complex genetic interaction analysis

Elena Kuzmin, Benjamin J VanderSluis, Alex N.Nguyen Ba, Wen Wang, Elizabeth N. Koch, Matej Usaj, Anton Khmelinskii, Mojca Mattiazzi Usaj, Jolanda Van Leeuwen, Oren Kraus, Amy Tresenrider, Michael Pryszlak, Ming Che Hu, Brenda Varriano, Michael Costanzo, Michael Knop, Alan Moses, Chad L. Myers, Brenda J. Andrews, Charles Boone

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Abstract

Whole-genome duplication has played a central role in the genome evolution of many organisms, including the human genome. Most duplicated genes are eliminated, and factors that influence the retention of persisting duplicates remain poorly understood. We describe a systematic complex genetic interaction analysis with yeast paralogs derived from the whole-genome duplication event. Mapping of digenic interactions for a deletion mutant of each paralog, and of trigenic interactions for the double mutant, provides insight into their roles and a quantitative measure of their functional redundancy. Trigenic interaction analysis distinguishes two classes of paralogs: A more functionally divergent subset and another that retained more functional overlap. Gene feature analysis and modeling suggest that evolutionary trajectories of duplicated genes are dictated by combined functional and structural entanglement factors.

Original language	English (US)
Article number	aaz5667
Journal	Science
Volume	368
Issue number	6498
DOIs	https://doi.org/10.1126/science.aaz5667
State	Published - Jun 26 2020
Externally published	Yes

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© 2020 American Association for the Advancement of Science. All rights reserved.

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Kuzmin, E., VanderSluis, B. J., Ba, A. N. N., Wang, W., Koch, E. N., Usaj, M., Khmelinskii, A., Usaj, M. M., Leeuwen, J. V., Kraus, O., Tresenrider, A., Pryszlak, M., Hu, M. C., Varriano, B., Costanzo, M., Knop, M., Moses, A., Myers, C. L., Andrews, B. J., & Boone, C. (2020). Exploring whole-genome duplicate gene retention with complex genetic interaction analysis. Science, 368(6498), Article aaz5667. https://doi.org/10.1126/science.aaz5667

Kuzmin, E, VanderSluis, BJ, Ba, ANN, Wang, W, Koch, EN, Usaj, M, Khmelinskii, A, Usaj, MM, Leeuwen, JV, Kraus, O, Tresenrider, A, Pryszlak, M, Hu, MC, Varriano, B, Costanzo, M, Knop, M, Moses, A, Myers, CL, Andrews, BJ & Boone, C 2020, 'Exploring whole-genome duplicate gene retention with complex genetic interaction analysis', Science, vol. 368, no. 6498, aaz5667. https://doi.org/10.1126/science.aaz5667

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Exploring whole-genome duplicate gene retention with complex genetic interaction analysis

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