Fibroblast growth factor 19 (FGF19) is a new member of the FGF family of growth factors. Here, we describe the localization of Fgf19 mRNA in the developing chick retina and lens in stages from the Hamburger and Hamilton stage 15 (HH15) to postnatal day 30 (P30). Fgf19 was expressed in a transient manner in postmitotic neuroblasts during the migration from the ventricular surface to their final location. Moreover, from HH31 (embryonic day 7, E7) on, a subset of lined up Fgf19 expressing cells was distributed in the outer region of the presumptive INL. These cells were Pax6 immunoreactive horizontal cells. During the last third of embryogenesis, Fgf19 expression in the retina was progressively down-regulated and was not detected at P30. Also, it was transiently expressed in the equatorial region of the lens.
Bibliographical noteFunding Information:
Thanks are due to María Salud Holguín-Arévalo and Miguel Ángel Ortiz-Ortiz for providing expert technical assistance. We are grateful to Joaquín Rodríguez-León and William Wood for insightful comments that helped contribute to the final form of the manuscript. During this work, JFM was the recipient of a fellowship from the Consejería de Educación, Ciencia y Tecnología, Junta de Extremadura and Fondo Social Europeo. HSC was the recipient of a studentship from the Spanish Ministry of Education and Culture. This work was supported by the Spanish Ministry of Science and Technology (PB97-0364) and the Junta de Extremadura (IPR98C028 and 2PR02A077). YK and JCIB are supported by grants from The G. Harold and Leila Y. Mathers Foundation and the NIH.
- Chick embryo
- Gradients of differentiation
- Retinal development
- Retinal neuroblasts