Expression of focal adhesion kinase in cardiac myocytes of hypertrophic ventricle

Zhan Yu Li, Xian Ping Yi, Ling Zhong, Fa Qian Li, Wen Ying Zhou, Wan Wei Cao, Yan Xuan Zheng, Xiao Hong Wang, Ya Nan Wang

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Objectives: To investigate the role of focal adhesion kinase (FAK) in the pathogenesis of cardiac hypertrophy induced by hypertension. Methods: Using immunofluorescent labeling, confocal microscopy and Western blotting, the expression and subcellular localization of FAK in the cardiac myocytes of left ventricle were determined in 2, 6, 12, and 18 month-old rats with spontaneously hypertensive heart failure (SHHF) along with age-matched control Wistar-Kyoto (WKY) rats. Results: There was no significant difference of FAK expression between 2 month-old SHHF and WKY rats(50.5 ± 6.9 vs. 49.8 ± 5.0, n = 6, P > 0.05). In contrast with the control groups, the expression of FAK significantly increased in 6, 12 and 18 month-old SHHF rats (130.6 ± 3.0 vs. 47.3 ± 1.3, 144.7 ± 5.4 vs. 46.4 ± 3.1, 141.4 ± 9.8 vs. 48.5 ± 2.2, each groups n = 6, P < 0.05) with FAK protein primarily cumulated in the intercalated disks and nuclei. Conclusions: FAK may play a role in the cell signaling transduction leading to cardiac hypertrophy, presumably through regulations of hypertrophic gene transcription and RNA processing.

Original languageEnglish (US)
Pages (from-to)677-680
Number of pages4
JournalChinese Journal of Pathology
Volume36
Issue number10
StatePublished - Oct 1 2007

Keywords

  • Adaptor proteins, signaling transducing
  • Cardiomyopathies
  • Focal adhesion kinase 1
  • Hypertension

Fingerprint Dive into the research topics of 'Expression of focal adhesion kinase in cardiac myocytes of hypertrophic ventricle'. Together they form a unique fingerprint.

Cite this