Expression of monocarboxylate transporter MCT1 in normal and neoplastic human CNS tissues

M. Kent Froberg; David Z. Gerhart; Bradley E. Enerson; Carlos Manivel; Manuel Guzman-Paz; Nicole Seacotte; Lester R Drewes

doi:10.1097/00001756-200103260-00030

Expression of monocarboxylate transporter MCT1 in normal and neoplastic human CNS tissues

M. Kent Froberg, David Z. Gerhart, Bradley E. Enerson, Carlos Manivel, Manuel Guzman-Paz, Nicole Seacotte, Lester R Drewes

Biomedical Sciences

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Abstract

Expression of monocarboxylate transporter MCT1 was studied in archival tissues from human CNS using antibodies to the carboxyl-terminal end of MCT1. Sections of neocortex, hippocampus and cerebellum of brains from 10 adult autopsy patients who died from other than CNS disease, and from archival surgical biopsy specimens of 83 primary CNS and eight non-CNS tumors were studied. MCT1 immunoreactivity was present in microvessels and, ependymocytes of normal CNS tissues similar to that reported for MCT1 expression in rat brains. MCT1 immunoreactivity was strongest in ependymomas, hemangioblastomas and high grade glial neoplasms, and weakest in low grade gliomas. Increased MCT1 expression in high grade glial neoplasms may provide a potential therapeutic target for treatment of some CNS neoplasms.

Original language	English (US)
Pages (from-to)	761-765
Number of pages	5
Journal	Neuroreport
Volume	12
Issue number	4
DOIs	https://doi.org/10.1097/00001756-200103260-00030
State	Published - Mar 26 2001

Keywords

Cerebral energy metabolism
Lactate transporters

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AU - Gerhart, David Z.

AU - Enerson, Bradley E.

AU - Manivel, Carlos

AU - Guzman-Paz, Manuel

AU - Seacotte, Nicole

AU - Drewes, Lester R

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Expression of monocarboxylate transporter MCT1 in normal and neoplastic human CNS tissues

Abstract

Keywords

UN SDGs

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