Extending Cord Blood Transplant to Adults: Dealing With Problems and Results Overall

Claudio G Brunstein, Mary J. Laughlin

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

The development of newer strategies to overcome, in particular, the cell dose limitation, has increased the availability of umbilical cord blood (UCB) as a source of hematopoietic stem cells (HSC) for transplantation of adults. Among these strategies is the development of the double UCB, ex vivo, and reduced-intensity transplantation platforms. Several ongoing registry-based and single-institution and multicenter clinical trials are investigating ways to make UCB transplantation safer and to improve the outcomes of adults after UCB transplantation. We review the background data and promising newer strategies that will further expand the utilization of UCB for the treatment of adults.

Original languageEnglish (US)
Pages (from-to)86-96
Number of pages11
JournalSeminars in Hematology
Volume47
Issue number1
DOIs
StatePublished - Jan 1 2010

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