TY - JOUR
T1 - Extracellular vesicles as novel delivery tools for cancer treatment
AU - Erkan, Erdogan Pekcan
AU - Saydam, Okay
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Extracellular vesicles (EVs) are different types of membrane-derived vesicles that originate from the endosomal pathway or the plasma membrane. These vesicles are used as “carriers” in intercellular communication, and are responsible for the transfer of biological cargo (lipids, proteins, RNA species, and DNA) between different cells. Despite the shortcomings in our knowledge of EV biology, attempts to employ EVs as natural delivery tools for therapeutic purposes have been partly successful in different settings. In this review, we highlight this unique potential of EVs, and discuss previous examples and future scenarios.
AB - Extracellular vesicles (EVs) are different types of membrane-derived vesicles that originate from the endosomal pathway or the plasma membrane. These vesicles are used as “carriers” in intercellular communication, and are responsible for the transfer of biological cargo (lipids, proteins, RNA species, and DNA) between different cells. Despite the shortcomings in our knowledge of EV biology, attempts to employ EVs as natural delivery tools for therapeutic purposes have been partly successful in different settings. In this review, we highlight this unique potential of EVs, and discuss previous examples and future scenarios.
KW - Cancer
KW - Delivery
KW - Extracellular vesicles
KW - Therapeutics
UR - http://www.scopus.com/inward/record.url?scp=84953807288&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84953807288&partnerID=8YFLogxK
U2 - 10.2174/1568009615666150923115439
DO - 10.2174/1568009615666150923115439
M3 - Article
C2 - 26412464
AN - SCOPUS:84953807288
SN - 1568-0096
VL - 16
SP - 34
EP - 42
JO - Current Cancer Drug Targets
JF - Current Cancer Drug Targets
IS - 1
ER -
