Extranodal natural killer/T-cell lymphoma from skin or soft tissue: Suggestion of treatment from multinational retrospective analysis

H. K. Ahn; C. Suh; S. S. Chuang; J. Suzumiya; Y. H. Ko; S. J. Kim; J. R. Huh; D. H. Yoon; S. Y. Oh; J. S. Kim; S. I. Lee; K. W. Park; P. P. Hsieh; S. Nakamura; T. Yoshino; K. Ito; T. Nagatani; K. Oshimi; R. Suzuki; W. S. Kim

doi:10.1093/annonc/mds096

Extranodal natural killer/T-cell lymphoma from skin or soft tissue: Suggestion of treatment from multinational retrospective analysis

H. K. Ahn, C. Suh, S. S. Chuang, J. Suzumiya, Y. H. Ko, S. J. Kim, J. R. Huh, D. H. Yoon, S. Y. Oh, J. S. Kim, S. I. Lee, K. W. Park, P. P. Hsieh, S. Nakamura, T. Yoshino, K. Ito, T. Nagatani, K. Oshimi, R. Suzuki, W. S. Kim

Pediatrics - Blood/Marrow Transplant

Research output: Contribution to journal › Review article › peer-review

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Abstract

Background: Clinical features and outcomes of extranodal natural killer/T-cell lymphoma (ENKL) arising from extranasal sites are not fully understood. The purpose of this study was to study the prognosis and treatment outcome of skin/soft tissue primary ENKL. Patients and methods: This multicenter retrospective study included 48 patients with skin/soft tissue primary ENKL diagnosed from 1993 to 2010. Results: Patients with Ann Arbor stage I, T1-2N0M0 by International Society for Cutaneous Lymphomas-European Organization of Research and Treatment of Cancer TNM (tumour-node-metastasis) stage, International prognostic index score of 0-1, and a Korean prognostic index (KPI) score of 0-1 were associated with better survival. Four of five patients with T1-2N0M0 disease achieved complete response with radiation alone. In disseminated disease, only 6 of 13 patients responded to anthracycline-containing chemotherapy, and all the two patients receiving SMILE showed response. Conclusion: In conclusion, we identified the prognostic value of KPI, and we suggest a treatment recommendation according to the TNM (tumour-node-metastasis) stage. Radiotherapy with/without chemotherapy seemed to be optimal in localized disease. In advanced stages, a more aggressive treatment regimen with newer agents should be sought.

Original language	English (US)
Pages (from-to)	2703-2707
Number of pages	5
Journal	Annals of Oncology
Volume	23
Issue number	10
DOIs	https://doi.org/10.1093/annonc/mds096
State	Published - Oct 2012

Keywords

Chemotherapy
Extranodal NK/T-cell lymphoma
Prognosis
Radiation therapy
Skin

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Ahn, H. K., Suh, C., Chuang, S. S., Suzumiya, J., Ko, Y. H., Kim, S. J., Huh, J. R., Yoon, D. H., Oh, S. Y., Kim, J. S., Lee, S. I., Park, K. W., Hsieh, P. P., Nakamura, S., Yoshino, T., Ito, K., Nagatani, T., Oshimi, K., Suzuki, R., & Kim, W. S. (2012). Extranodal natural killer/T-cell lymphoma from skin or soft tissue: Suggestion of treatment from multinational retrospective analysis. Annals of Oncology, 23(10), 2703-2707. https://doi.org/10.1093/annonc/mds096

Ahn, HK, Suh, C, Chuang, SS, Suzumiya, J, Ko, YH, Kim, SJ, Huh, JR, Yoon, DH, Oh, SY, Kim, JS, Lee, SI, Park, KW, Hsieh, PP, Nakamura, S, Yoshino, T, Ito, K, Nagatani, T, Oshimi, K, Suzuki, R & Kim, WS 2012, 'Extranodal natural killer/T-cell lymphoma from skin or soft tissue: Suggestion of treatment from multinational retrospective analysis', Annals of Oncology, vol. 23, no. 10, pp. 2703-2707. https://doi.org/10.1093/annonc/mds096

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title = "Extranodal natural killer/T-cell lymphoma from skin or soft tissue: Suggestion of treatment from multinational retrospective analysis",

abstract = "Background: Clinical features and outcomes of extranodal natural killer/T-cell lymphoma (ENKL) arising from extranasal sites are not fully understood. The purpose of this study was to study the prognosis and treatment outcome of skin/soft tissue primary ENKL. Patients and methods: This multicenter retrospective study included 48 patients with skin/soft tissue primary ENKL diagnosed from 1993 to 2010. Results: Patients with Ann Arbor stage I, T1-2N0M0 by International Society for Cutaneous Lymphomas-European Organization of Research and Treatment of Cancer TNM (tumour-node-metastasis) stage, International prognostic index score of 0-1, and a Korean prognostic index (KPI) score of 0-1 were associated with better survival. Four of five patients with T1-2N0M0 disease achieved complete response with radiation alone. In disseminated disease, only 6 of 13 patients responded to anthracycline-containing chemotherapy, and all the two patients receiving SMILE showed response. Conclusion: In conclusion, we identified the prognostic value of KPI, and we suggest a treatment recommendation according to the TNM (tumour-node-metastasis) stage. Radiotherapy with/without chemotherapy seemed to be optimal in localized disease. In advanced stages, a more aggressive treatment regimen with newer agents should be sought.",

keywords = "Chemotherapy, Extranodal NK/T-cell lymphoma, Prognosis, Radiation therapy, Skin",

author = "Ahn, {H. K.} and C. Suh and Chuang, {S. S.} and J. Suzumiya and Ko, {Y. H.} and Kim, {S. J.} and Huh, {J. R.} and Yoon, {D. H.} and Oh, {S. Y.} and Kim, {J. S.} and Lee, {S. I.} and Park, {K. W.} and Hsieh, {P. P.} and S. Nakamura and T. Yoshino and K. Ito and T. Nagatani and K. Oshimi and R. Suzuki and Kim, {W. S.}",

year = "2012",

month = oct,

doi = "10.1093/annonc/mds096",

language = "English (US)",

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T1 - Extranodal natural killer/T-cell lymphoma from skin or soft tissue

T2 - Suggestion of treatment from multinational retrospective analysis

AU - Ahn, H. K.

AU - Suh, C.

AU - Chuang, S. S.

AU - Suzumiya, J.

AU - Ko, Y. H.

AU - Kim, S. J.

AU - Huh, J. R.

AU - Yoon, D. H.

AU - Oh, S. Y.

AU - Kim, J. S.

AU - Lee, S. I.

AU - Park, K. W.

AU - Hsieh, P. P.

AU - Nakamura, S.

AU - Yoshino, T.

AU - Ito, K.

AU - Nagatani, T.

AU - Oshimi, K.

AU - Suzuki, R.

AU - Kim, W. S.

PY - 2012/10

Y1 - 2012/10

N2 - Background: Clinical features and outcomes of extranodal natural killer/T-cell lymphoma (ENKL) arising from extranasal sites are not fully understood. The purpose of this study was to study the prognosis and treatment outcome of skin/soft tissue primary ENKL. Patients and methods: This multicenter retrospective study included 48 patients with skin/soft tissue primary ENKL diagnosed from 1993 to 2010. Results: Patients with Ann Arbor stage I, T1-2N0M0 by International Society for Cutaneous Lymphomas-European Organization of Research and Treatment of Cancer TNM (tumour-node-metastasis) stage, International prognostic index score of 0-1, and a Korean prognostic index (KPI) score of 0-1 were associated with better survival. Four of five patients with T1-2N0M0 disease achieved complete response with radiation alone. In disseminated disease, only 6 of 13 patients responded to anthracycline-containing chemotherapy, and all the two patients receiving SMILE showed response. Conclusion: In conclusion, we identified the prognostic value of KPI, and we suggest a treatment recommendation according to the TNM (tumour-node-metastasis) stage. Radiotherapy with/without chemotherapy seemed to be optimal in localized disease. In advanced stages, a more aggressive treatment regimen with newer agents should be sought.

AB - Background: Clinical features and outcomes of extranodal natural killer/T-cell lymphoma (ENKL) arising from extranasal sites are not fully understood. The purpose of this study was to study the prognosis and treatment outcome of skin/soft tissue primary ENKL. Patients and methods: This multicenter retrospective study included 48 patients with skin/soft tissue primary ENKL diagnosed from 1993 to 2010. Results: Patients with Ann Arbor stage I, T1-2N0M0 by International Society for Cutaneous Lymphomas-European Organization of Research and Treatment of Cancer TNM (tumour-node-metastasis) stage, International prognostic index score of 0-1, and a Korean prognostic index (KPI) score of 0-1 were associated with better survival. Four of five patients with T1-2N0M0 disease achieved complete response with radiation alone. In disseminated disease, only 6 of 13 patients responded to anthracycline-containing chemotherapy, and all the two patients receiving SMILE showed response. Conclusion: In conclusion, we identified the prognostic value of KPI, and we suggest a treatment recommendation according to the TNM (tumour-node-metastasis) stage. Radiotherapy with/without chemotherapy seemed to be optimal in localized disease. In advanced stages, a more aggressive treatment regimen with newer agents should be sought.

KW - Chemotherapy

KW - Extranodal NK/T-cell lymphoma

KW - Prognosis

KW - Radiation therapy

KW - Skin

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SN - 0923-7534

VL - 23

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EP - 2707

JO - Annals of Oncology

JF - Annals of Oncology

IS - 10

ER -

Extranodal natural killer/T-cell lymphoma from skin or soft tissue: Suggestion of treatment from multinational retrospective analysis

Abstract

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