Extraordinary metabolic stability of peptides containing α-aminoxy acids

Fei Chen, Bin Ma, Zong Chang Yang, Ge Lin, Dan Yang

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

The metabolic stability of peptides containing a mixed sequence of α-aminoxy acids and α-amino acids is significantly improved compared to peptides composed of only natural α-amino acids. The introduction of an α-aminoxy acid into peptide chain dramatically improves the stability of the amide bonds immediately before and after it. These peptides containing α-aminoxy acids represent excellent structural scaffold for the design of metabolically stable and biologically active peptides.

Original languageEnglish (US)
Pages (from-to)499-503
Number of pages5
JournalAmino Acids
Volume43
Issue number1
DOIs
StatePublished - Jul 2012

Bibliographical note

Funding Information:
This work was supported by Hong Kong Research Grants Council (HKU 2/06C and HKU8CRF10) and Chinese University of Hong Kong Direct Grant (2041542).

Keywords

  • Aminoxy acid
  • Metabolism
  • Peptides
  • Stability

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