The metabolic stability of peptides containing a mixed sequence of α-aminoxy acids and α-amino acids is significantly improved compared to peptides composed of only natural α-amino acids. The introduction of an α-aminoxy acid into peptide chain dramatically improves the stability of the amide bonds immediately before and after it. These peptides containing α-aminoxy acids represent excellent structural scaffold for the design of metabolically stable and biologically active peptides.
Bibliographical noteFunding Information:
This work was supported by Hong Kong Research Grants Council (HKU 2/06C and HKU8CRF10) and Chinese University of Hong Kong Direct Grant (2041542).
- Aminoxy acid