Extraordinary metabolic stability of peptides containing α-aminoxy acids

Fei Chen; Bin Ma; Zong Chang Yang; Ge Lin; Dan Yang

doi:10.1007/s00726-011-1095-8

Extraordinary metabolic stability of peptides containing α-aminoxy acids

Fei Chen, Bin Ma, Zong Chang Yang, Ge Lin, Dan Yang

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

The metabolic stability of peptides containing a mixed sequence of α-aminoxy acids and α-amino acids is significantly improved compared to peptides composed of only natural α-amino acids. The introduction of an α-aminoxy acid into peptide chain dramatically improves the stability of the amide bonds immediately before and after it. These peptides containing α-aminoxy acids represent excellent structural scaffold for the design of metabolically stable and biologically active peptides.

Original language	English (US)
Pages (from-to)	499-503
Number of pages	5
Journal	Amino Acids
Volume	43
Issue number	1
DOIs	https://doi.org/10.1007/s00726-011-1095-8
State	Published - Jul 2012
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by Hong Kong Research Grants Council (HKU 2/06C and HKU8CRF10) and Chinese University of Hong Kong Direct Grant (2041542).

Keywords

Aminoxy acid
Metabolism
Peptides
Stability

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AU - Chen, Fei

AU - Ma, Bin

AU - Yang, Zong Chang

AU - Lin, Ge

AU - Yang, Dan

N1 - Funding Information: This work was supported by Hong Kong Research Grants Council (HKU 2/06C and HKU8CRF10) and Chinese University of Hong Kong Direct Grant (2041542).

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N2 - The metabolic stability of peptides containing a mixed sequence of α-aminoxy acids and α-amino acids is significantly improved compared to peptides composed of only natural α-amino acids. The introduction of an α-aminoxy acid into peptide chain dramatically improves the stability of the amide bonds immediately before and after it. These peptides containing α-aminoxy acids represent excellent structural scaffold for the design of metabolically stable and biologically active peptides.

AB - The metabolic stability of peptides containing a mixed sequence of α-aminoxy acids and α-amino acids is significantly improved compared to peptides composed of only natural α-amino acids. The introduction of an α-aminoxy acid into peptide chain dramatically improves the stability of the amide bonds immediately before and after it. These peptides containing α-aminoxy acids represent excellent structural scaffold for the design of metabolically stable and biologically active peptides.

KW - Aminoxy acid

KW - Metabolism

KW - Peptides

KW - Stability

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Extraordinary metabolic stability of peptides containing α-aminoxy acids

Abstract

Bibliographical note

Keywords

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