TY - JOUR
T1 - Extravirgin olive oil consumption reduces risk of atrial fibrillation
T2 - The PREDIMED (Prevención con Dieta Mediterránea) trial
AU - Martínez-González, Miguel Á
AU - Toledo, Estefanía
AU - Arós, Fernando
AU - Fiol, Miquel
AU - Corella, Dolores
AU - Salas-Salvadó, Jordi
AU - Ros, Emilio
AU - Covas, Maria I.
AU - Fernández-Crehuet, Joaquín
AU - Lapetra, José
AU - Muñoz, Miguel A.
AU - Fitó, Monserrat
AU - Serra-Majem, Luis
AU - Pintó, Xavier
AU - Lamuela-Raventós, Rosa M.
AU - Sorlí, Jose V.
AU - Babio, Nancy
AU - Buil-Cosiales, Pilar
AU - Ruiz-Gutierrez, Valentina
AU - Estruch, Ramón
AU - Alonso, Alvaro
PY - 2014/7/1
Y1 - 2014/7/1
N2 - Background - The PREDIMED (Prevención con Dieta Mediterránea) randomized primary prevention trial showed that a Mediterranean diet enriched with either extravirgin olive oil or mixed nuts reduces the incidence of stroke, myocardial infarction, and cardiovascular mortality. We assessed the effect of these diets on the incidence of atrial fibrillation in the PREDIMED trial. Methods and Results - Participants were randomly assigned to 1 of 3 diets: Mediterranean diet supplemented with extravirgin olive oil, Mediterranean diet supplemented with mixed nuts, or advice to follow a low-fat diet (control group). Incident atrial fibrillation was adjudicated during follow-up by an events committee blinded to dietary group allocation. Among 6705 participants without prevalent atrial fibrillation at randomization, we observed 72 new cases of atrial fibrillation in the Mediterranean diet with extravirgin olive oil group, 82 in the Mediterranean diet with mixed nuts group, and 92 in the control group after median follow-up of 4.7 years. The Mediterranean diet with extravirgin olive oil significantly reduced the risk of atrial fibrillation (hazard ratio, 0.62; 95% confidence interval, 0.45-0.85 compared with the control group). No effect was found for the Mediterranean diet with nuts (hazard ratio, 0.89; 95% confidence interval, 0.65-1.20). Conclusions - In the absence of proven interventions for the primary prevention of atrial fibrillation, this post hoc analysis of the PREDIMED trial suggests that extravirgin olive oil in the context of a Mediterranean dietary pattern may reduce the risk of atrial fibrillation.
AB - Background - The PREDIMED (Prevención con Dieta Mediterránea) randomized primary prevention trial showed that a Mediterranean diet enriched with either extravirgin olive oil or mixed nuts reduces the incidence of stroke, myocardial infarction, and cardiovascular mortality. We assessed the effect of these diets on the incidence of atrial fibrillation in the PREDIMED trial. Methods and Results - Participants were randomly assigned to 1 of 3 diets: Mediterranean diet supplemented with extravirgin olive oil, Mediterranean diet supplemented with mixed nuts, or advice to follow a low-fat diet (control group). Incident atrial fibrillation was adjudicated during follow-up by an events committee blinded to dietary group allocation. Among 6705 participants without prevalent atrial fibrillation at randomization, we observed 72 new cases of atrial fibrillation in the Mediterranean diet with extravirgin olive oil group, 82 in the Mediterranean diet with mixed nuts group, and 92 in the control group after median follow-up of 4.7 years. The Mediterranean diet with extravirgin olive oil significantly reduced the risk of atrial fibrillation (hazard ratio, 0.62; 95% confidence interval, 0.45-0.85 compared with the control group). No effect was found for the Mediterranean diet with nuts (hazard ratio, 0.89; 95% confidence interval, 0.65-1.20). Conclusions - In the absence of proven interventions for the primary prevention of atrial fibrillation, this post hoc analysis of the PREDIMED trial suggests that extravirgin olive oil in the context of a Mediterranean dietary pattern may reduce the risk of atrial fibrillation.
KW - Antioxidants
KW - Arrhythmia
KW - Atrial fibrillation
KW - Diet
KW - Epidemiology
KW - Fatty acids
KW - Inflammation
KW - Monounsaturated
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U2 - 10.1161/CIRCULATIONAHA.113.006921
DO - 10.1161/CIRCULATIONAHA.113.006921
M3 - Article
C2 - 24787471
AN - SCOPUS:84903735461
SN - 0009-7322
VL - 130
SP - 18
EP - 26
JO - Circulation
JF - Circulation
IS - 1
ER -