Extreme sensitivity of diabetic mice to naloxone-induced suppression of food intake

Allen S Levine; J. E. Morley; D. M. Brown; B. S. Handwerger

doi:10.1016/0031-9384(82)90164-0

Extreme sensitivity of diabetic mice to naloxone-induced suppression of food intake

Allen S Levine, J. E. Morley, D. M. Brown, B. S. Handwerger

Food Science and Nutrition

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

Alterations in serum glucose concentration have been shown to modulate the responsiveness of animals to opiates. In the present study we found that genetically obese diabetic mice (C57 BL/Ks-db+/db+) were about 80 times more sensitive to the suppressive effect of naloxone on food intake than their heterozygote littermate controls. Streptozotocin-induced diabetic mice were 1000 times more sensitive to naloxone's inhibitory effect on feeding than were their controls. These results suggest that high serum glucose levels, rather than obesity, induce extreme sensitivity to naloxone-induced suppression of food intake.

Original language	English (US)
Pages (from-to)	987-989
Number of pages	3
Journal	Physiology and Behavior
Volume	28
Issue number	6
DOIs	https://doi.org/10.1016/0031-9384(82)90164-0
State	Published - Jun 1982

Bibliographical note

Funding Information:
We thank Julie Kneip and Sheryl Hess for their excellent technical assistance, and JoAnn Tallman for her secretarial aid. This work was supported by the American Diabetes Association, the American Diabetes Association of Minnesota, USPHS grant AM 25879 and the Veterans Administration. Dr. Handwerger was a recipient of a Veterans Administration Cfinical Investigator award.

Keywords

Diabetes
Food intake
Naloxone
Opiates
Streptozotocin

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title = "Extreme sensitivity of diabetic mice to naloxone-induced suppression of food intake",

abstract = "Alterations in serum glucose concentration have been shown to modulate the responsiveness of animals to opiates. In the present study we found that genetically obese diabetic mice (C57 BL/Ks-db+/db+) were about 80 times more sensitive to the suppressive effect of naloxone on food intake than their heterozygote littermate controls. Streptozotocin-induced diabetic mice were 1000 times more sensitive to naloxone's inhibitory effect on feeding than were their controls. These results suggest that high serum glucose levels, rather than obesity, induce extreme sensitivity to naloxone-induced suppression of food intake.",

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AU - Handwerger, B. S.

N1 - Funding Information: We thank Julie Kneip and Sheryl Hess for their excellent technical assistance, and JoAnn Tallman for her secretarial aid. This work was supported by the American Diabetes Association, the American Diabetes Association of Minnesota, USPHS grant AM 25879 and the Veterans Administration. Dr. Handwerger was a recipient of a Veterans Administration Cfinical Investigator award.

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AB - Alterations in serum glucose concentration have been shown to modulate the responsiveness of animals to opiates. In the present study we found that genetically obese diabetic mice (C57 BL/Ks-db+/db+) were about 80 times more sensitive to the suppressive effect of naloxone on food intake than their heterozygote littermate controls. Streptozotocin-induced diabetic mice were 1000 times more sensitive to naloxone's inhibitory effect on feeding than were their controls. These results suggest that high serum glucose levels, rather than obesity, induce extreme sensitivity to naloxone-induced suppression of food intake.

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Extreme sensitivity of diabetic mice to naloxone-induced suppression of food intake

Abstract

Bibliographical note

Keywords

UN SDGs

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