TY - JOUR
T1 - Ezrin, Radixin and Moesin
T2 - Key regulators of membrane-cortex interactions and signaling
AU - Neisch, Amanda L.
AU - Fehon, Richard G.
N1 - Funding Information:
The authors would like to thank the members of the Fehon laboratory for helpful comments and discussions. This work is supported by NIH R01 GM087558 .
PY - 2011/8
Y1 - 2011/8
N2 - The cell cortex serves as a critical nexus between the extracellular environment/cell membrane and the underlying cytoskeleton and cytoplasm. In many cells, the cell cortex is organized and maintained by the Ezrin, Radixin and Moesin (ERM) proteins, which have the ability to interact with both the plasma membrane and filamentous actin. Although this membrane-cytoskeletal linkage function is critical to stability of the cell cortex, recent studies indicate that this is only a part of what ERMs do in many cells. In addition to their role in binding filamentous actin, ERMs regulate signaling pathways through their ability to bind transmembrane receptors and link them to downstream signaling components. In this review we discuss recent evidence in a variety of cells indicating that ERMs serve as scaffolds to facilitate efficient signal transduction on the cytoplasmic face of the plasma membrane.
AB - The cell cortex serves as a critical nexus between the extracellular environment/cell membrane and the underlying cytoskeleton and cytoplasm. In many cells, the cell cortex is organized and maintained by the Ezrin, Radixin and Moesin (ERM) proteins, which have the ability to interact with both the plasma membrane and filamentous actin. Although this membrane-cytoskeletal linkage function is critical to stability of the cell cortex, recent studies indicate that this is only a part of what ERMs do in many cells. In addition to their role in binding filamentous actin, ERMs regulate signaling pathways through their ability to bind transmembrane receptors and link them to downstream signaling components. In this review we discuss recent evidence in a variety of cells indicating that ERMs serve as scaffolds to facilitate efficient signal transduction on the cytoplasmic face of the plasma membrane.
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U2 - 10.1016/j.ceb.2011.04.011
DO - 10.1016/j.ceb.2011.04.011
M3 - Review article
C2 - 21592758
AN - SCOPUS:79960733700
SN - 0955-0674
VL - 23
SP - 377
EP - 382
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 4
ER -