Factors Influencing Electrode Position and Bending of the Proximal Lead in Deep Brain Stimulation for Movement Disorders

Jacob Niederer, Rémi Patriat, Oren Rosenberg, Tara Palnitkar, David Darrow, Michael C. Park, Lauren Schrock, Lynn E. Eberly, Noam Harel

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The introduction of intracranial air (ICA) during deep brain stimulation (DBS) surgery is thought to have a negative influence on targeting and clinical outcomes. Objective: To investigate ICA volumes following surgery and other patient-specific factors as potential variables influencing translocation of the DBS electrode and proximal lead bowing. Methods: High-resolution postoperative computed tomography scans (≤1.0 mm resolution in all directions) within 24 h following DBS surgery and 4-6 weeks of follow-up were acquired. A total of 50 DBS leads in 33 patients were available for analysis. DBS leads included Abbott/St. Jude Medical InfinityTM, Boston Scientific VerciseTM, and Medtronic 3389TM. Results: Both ICA volume and anatomical target were significantly associated with measures of DBS electrode translocation. ICA volume and DBS lead model were found to be significant predictors of proximal lead bowing. Measures of proximal lead bowing and translocation along the electrode trajectory for the Medtronic 3389TM DBS lead were significantly larger than measures for the Abbott/St. Jude Medical InfinityTM and Boston Scientific VerciseTM DBS leads. Conclusion: The association between ICA volume and translocation of the DBS electrode is small in magnitude and not clinically relevant for DBS cases within a normal range of postoperative subdural air volumes. Differences in proximal lead bowing observed between DBS leads may reflect hardware engineering subtleties in the construction of DBS lead models.

Original languageEnglish (US)
Pages (from-to)300-312
Number of pages13
JournalStereotactic and Functional Neurosurgery
Volume98
Issue number5
DOIs
StatePublished - Sep 1 2020

Bibliographical note

Funding Information:
The research reported in this paper was supported in part by grants from the National Institutes of Health (R01-NS085188), the National Institute of Biomedical Imaging and Bioengineering (P41 EB015894), NINDS Institutional Center Core Grants to Support Neuroscience Research (P30 NS076408), and the University of Minnesota Udall Center (P50NS098573).

Publisher Copyright:
© 2020 S. Karger AG, Basel. Copyright: All rights reserved.

Keywords

  • Brain shift
  • Deep brain stimulation
  • Electrode translocation
  • Intracranial air volume
  • Proximal lead bowing

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural

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