Familial aggregation of blood lipid response to exercise training in the Health, Risk Factors, Exercise Training, and Genetics (HERITAGE) Family Study

Treva Rice, Jean Pierre Després, Louis Pérusse, Yuling Hong, Michael A. Province, Jean Bergeron, Jacques Gagnon, Arthur S. Leon, James S. Skinner, Jack H. Wilmore, Claude Bouchard, D. C. Rao

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Background - Fasting levels of plasma lipids and lipoproteins are reported to improve with regular exercise training. However, little is known on whether the training responses are influenced by heritable factors. Methods and Results - The lipid profile was assessed in 115 black (224 individuals) and 99 white families (469 individuals), who participated in the HERITAGE Family Study, while in a sedentary state (baseline visit) and after exercise training for 20 weeks (post visit). Variables included total cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (ApoB), high-density lipoprotein cholesterol (HDL-C), apolipoprotein A-I, and HDL-C subfractions 2 (HDL2-C) and 3 (HDL3-C). Familial correlations for the training responses (Δ=post-baseline) were significant for most variables, and the percent variance accounted for by familial factors (ie, maximal heritabilities) ranged from 25% to 38%. Exceptions were for higher heritabilities near 60% for ΔApoB in blacks and ΔHDL2-C in whites and a lower estimate of zero for ΔLDL-C in blacks. Conclusions - Heritable factors in part determine lipid profile responses to regular exercise. Maximal heritabilities were similar across ethnic groups and variables, except for ΔLDL-C, ΔApoB, and ΔHDL2-C. Molecular studies to identify the markers and genes associated with these influences are currently underway.

Original languageEnglish (US)
Pages (from-to)1904-1908
Number of pages5
JournalCirculation
Volume105
Issue number16
DOIs
StatePublished - Apr 23 2002

Keywords

  • Exercise
  • Genetics
  • Heritability
  • Lipids

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