Familial interruption of the aortic arch

Jennifer W. Gobel, Mary Ella M Pierpont, James H Moller, Amarjit Singh, Jesse E. Edwards

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Interruption of the aortic arch (IAA) is an important congenital cardiac malformation occurring in 1.4% of cases with a congenital cardiac malformation. Only two reports have described IAA in siblings, each with type B and an anomalous right subclavian artery. We report the occurrence of IAA type B with an anomalous right subclavian artery in two siblings and their half-sibling, each of whom had additional conotruncal cardiac malformations. Recent evidence suggests that conotruncal cardiac malformations, including IAA type B, are related to abnormalities of neural crest cell migration. Thus, the family reported herein may manifest a syndrome related to alterations in mesenchymal tissue/neural crest cell migration.

Original languageEnglish (US)
Pages (from-to)110-115
Number of pages6
JournalPediatric Cardiology
Volume14
Issue number2
DOIs
StatePublished - Mar 1 1993

Keywords

  • Conotruncal malformations
  • Familial cardiac anomaly
  • Interruption of the aortic arch

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