Familial resemblance for resting blood pressure with particular reference to racial differences: Preliminary analyses from the HERITAGE family study

Chi Gu, Ingrid Borecki, Jacques Gagnon, Claude Bouchard, Arthur S. Leon, James S. Skinner, Jack H. Wilmore, D. C. Rao

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Resting blood pressure in both white and black families participating in the HERITAGE Family Study was analyzed using a simple familial correlation model to assess familial influences. The two samples of black and white families were analyzed separately and together, providing an opportunity to test for heterogeneity in the familial resemblance. Maximal heritability was 46% for systolic blood pressure (SBP) and 31% for diastolic blood pressure (DBP) in the pooled sample. Noticeably higher heritabilities were found in the black sample (68% for SBP and 56% for DBP) than in the white sample (43% for SBP and 24% for DBP). The patterns of familial correlations were similar in blacks and whites, with the exception that spouse resemblance was significant in white families but not in black families. These results along with the finding that the magnitude of the familial correlations was higher in the black sample than in the white sample suggest that the effects of host and familial environmental factors differ between the races.

Original languageEnglish (US)
Pages (from-to)77-90
Number of pages14
JournalHuman Biology
Volume70
Issue number1
StatePublished - Feb 1998

Keywords

  • African Americans
  • Blacks
  • Blood Pressure
  • Familial Correlations
  • Heritage Family Study
  • Population Heterogeneity
  • Whites

Fingerprint Dive into the research topics of 'Familial resemblance for resting blood pressure with particular reference to racial differences: Preliminary analyses from the HERITAGE family study'. Together they form a unique fingerprint.

Cite this