Fascinating frontiers of N/O-functionalized N-heterocyclic carbene chemistry: From chemical catalysis to biomedical applications

Alex John, Prasenjit Ghosh

Research output: Contribution to journalReview articlepeer-review

159 Scopus citations

Abstract

The in vogue N-heterocyclic carbenes (NHCs) have attracted attention largely for its new found popularity in chemical catalysis and also for displaying promising traits in biomedical applications. The current perspective provides an account of our efforts in exploring the utility of N/O-functionalized N-heterocyclic carbenes in these two areas. On the catalysis front, we have employed the N/O-functionalized N-heterocyclic carbene based precatalysts for the C-C and C-N bond forming reactions like the Suzuki-Miyaura, Sonogashira and Hiyama cross-couplings, the base-free Michael addition, the alkene and alkyne hydroamination reactions and the ring-opening polymerization (ROP) of L-lactides that produce biodegradable polylactide polymers while on the biomedical application front, the anticancer and antimicrobial properties of these N/O-functionalized N-heterocyclic carbene complexes were evaluated. Towards this objective, the N-heterocyclic carbene chemistry of a variety of transition metals like Ag, Au, Ni and Pd has been investigated.

Original languageEnglish (US)
Pages (from-to)7183-7206
Number of pages24
JournalDalton Transactions
Volume39
Issue number31
DOIs
StatePublished - Aug 21 2010

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