Do stable intermediates form very early in the protein folding process? New results and a quantity of literature that bear on this issue are examined here. Results available provide little support for early intermediate accumulation before an initial search-dependent nucleation barrier.
Bibliographical noteFunding Information:
We thank Y. Bai, D. Baker, R. L. Baldwin, W. Eaton, N. R. Kallenbach, I. Morishima, T. Pan, S. Radford, H. Roder, D. Rousseau, and members of our groups for numerous helpful discussions. This work was supported by grants from the NIH, the Mathers Foundation, and the Packard Foundation Interdisciplinary Science Program.
Copyright 2020 Elsevier B.V., All rights reserved.
- Barriers in protein folding
- Burst phase
- Initial barrier hypothesis
- Intermediates in protein folding
- Protein folding