Fast and slow intermediate accumulation and the initial barrier mechanism in protein folding

Bryan A. Krantz; Leland Mayne; Jon Rumbley; S. Walter Englander; Tobin R. Sosnick

doi:10.1016/S0022-2836(02)01029-X

Fast and slow intermediate accumulation and the initial barrier mechanism in protein folding

Bryan A. Krantz, Leland Mayne, Jon Rumbley, S. Walter Englander, Tobin R. Sosnick

Duluth Pharmacy Program

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151 Scopus citations

Abstract

Do stable intermediates form very early in the protein folding process? New results and a quantity of literature that bear on this issue are examined here. Results available provide little support for early intermediate accumulation before an initial search-dependent nucleation barrier.

Original language	English (US)
Pages (from-to)	359-371
Number of pages	13
Journal	Journal of Molecular Biology
Volume	324
Issue number	2
DOIs	https://doi.org/10.1016/S0022-2836(02)01029-X
State	Published - 2002

Bibliographical note

Funding Information:
We thank Y. Bai, D. Baker, R. L. Baldwin, W. Eaton, N. R. Kallenbach, I. Morishima, T. Pan, S. Radford, H. Roder, D. Rousseau, and members of our groups for numerous helpful discussions. This work was supported by grants from the NIH, the Mathers Foundation, and the Packard Foundation Interdisciplinary Science Program.

Keywords

Barriers in protein folding
Burst phase
Initial barrier hypothesis
Intermediates in protein folding
Protein folding

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title = "Fast and slow intermediate accumulation and the initial barrier mechanism in protein folding",

abstract = "Do stable intermediates form very early in the protein folding process? New results and a quantity of literature that bear on this issue are examined here. Results available provide little support for early intermediate accumulation before an initial search-dependent nucleation barrier.",

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note = "Funding Information: We thank Y. Bai, D. Baker, R. L. Baldwin, W. Eaton, N. R. Kallenbach, I. Morishima, T. Pan, S. Radford, H. Roder, D. Rousseau, and members of our groups for numerous helpful discussions. This work was supported by grants from the NIH, the Mathers Foundation, and the Packard Foundation Interdisciplinary Science Program.",

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AU - Mayne, Leland

AU - Rumbley, Jon

AU - Englander, S. Walter

AU - Sosnick, Tobin R.

N1 - Funding Information: We thank Y. Bai, D. Baker, R. L. Baldwin, W. Eaton, N. R. Kallenbach, I. Morishima, T. Pan, S. Radford, H. Roder, D. Rousseau, and members of our groups for numerous helpful discussions. This work was supported by grants from the NIH, the Mathers Foundation, and the Packard Foundation Interdisciplinary Science Program.

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AB - Do stable intermediates form very early in the protein folding process? New results and a quantity of literature that bear on this issue are examined here. Results available provide little support for early intermediate accumulation before an initial search-dependent nucleation barrier.

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KW - Initial barrier hypothesis

KW - Intermediates in protein folding

KW - Protein folding

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Fast and slow intermediate accumulation and the initial barrier mechanism in protein folding

Abstract

Bibliographical note

Keywords

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