Fast and slow intermediate accumulation and the initial barrier mechanism in protein folding

Bryan A. Krantz, Leland Mayne, Jon Rumbley, S. Walter Englander, Tobin R. Sosnick

Research output: Contribution to journalArticlepeer-review

145 Scopus citations

Abstract

Do stable intermediates form very early in the protein folding process? New results and a quantity of literature that bear on this issue are examined here. Results available provide little support for early intermediate accumulation before an initial search-dependent nucleation barrier.

Original languageEnglish (US)
Pages (from-to)359-371
Number of pages13
JournalJournal of Molecular Biology
Volume324
Issue number2
DOIs
StatePublished - 2002

Bibliographical note

Funding Information:
We thank Y. Bai, D. Baker, R. L. Baldwin, W. Eaton, N. R. Kallenbach, I. Morishima, T. Pan, S. Radford, H. Roder, D. Rousseau, and members of our groups for numerous helpful discussions. This work was supported by grants from the NIH, the Mathers Foundation, and the Packard Foundation Interdisciplinary Science Program.

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

Keywords

  • Barriers in protein folding
  • Burst phase
  • Initial barrier hypothesis
  • Intermediates in protein folding
  • Protein folding

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