Fatal Disseminated Aspergillosis following Sequential Heart and Stem Cell Transplantation for Systemic Amyloidosis

Raymund R. Razonable; Robin Patel; Mark P. Wilhelm; Morie A. Gertz; Mark R. Litzow; David J. Inwards; Joseph A. Dearani; Brooks S. Edwards; Christopher G. McGregor

doi:10.1034/j.1600-6143.2001.010117.x

Fatal Disseminated Aspergillosis following Sequential Heart and Stem Cell Transplantation for Systemic Amyloidosis

Raymund R. Razonable, Robin Patel, Mark P. Wilhelm, Morie A. Gertz, Mark R. Litzow, David J. Inwards, Joseph A. Dearani, Brooks S. Edwards, Christopher G. McGregor

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6 Scopus citations

Abstract

Infectious complications are a major cause of morbidity and mortality in transplant recipients. We describe a case of fatal disseminated aspergillosis immediately following autologous peripheral stem cell reconstitution in a patient who had undergone orthotopic heart transplantation for systemic amyloidosis. The case described suggests that the infectious risks in patients undergoing these sequential procedures may be distinct from those occurring in patients undergoing either procedure independently. Potential prophylactic and therapeutic interventions are discussed. Since this experimental and evolving approach for the management of systemic amyloidosis is potentially applicable to a limited number of patients, multicenter collaboration may be needed to further define the infectious risks in this unique subset of transplant recipients.

Original language	English (US)
Pages (from-to)	93-95
Number of pages	3
Journal	American Journal of Transplantation
Volume	1
Issue number	1
DOIs	https://doi.org/10.1034/j.1600-6143.2001.010117.x
State	Published - May 2001
Externally published	Yes

Keywords

Amyloidosis
Aspergillosis
Heart transplant
Stem cell transplant

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abstract = "Infectious complications are a major cause of morbidity and mortality in transplant recipients. We describe a case of fatal disseminated aspergillosis immediately following autologous peripheral stem cell reconstitution in a patient who had undergone orthotopic heart transplantation for systemic amyloidosis. The case described suggests that the infectious risks in patients undergoing these sequential procedures may be distinct from those occurring in patients undergoing either procedure independently. Potential prophylactic and therapeutic interventions are discussed. Since this experimental and evolving approach for the management of systemic amyloidosis is potentially applicable to a limited number of patients, multicenter collaboration may be needed to further define the infectious risks in this unique subset of transplant recipients.",

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AU - Patel, Robin

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AU - Gertz, Morie A.

AU - Litzow, Mark R.

AU - Inwards, David J.

AU - Dearani, Joseph A.

AU - Edwards, Brooks S.

AU - McGregor, Christopher G.

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AB - Infectious complications are a major cause of morbidity and mortality in transplant recipients. We describe a case of fatal disseminated aspergillosis immediately following autologous peripheral stem cell reconstitution in a patient who had undergone orthotopic heart transplantation for systemic amyloidosis. The case described suggests that the infectious risks in patients undergoing these sequential procedures may be distinct from those occurring in patients undergoing either procedure independently. Potential prophylactic and therapeutic interventions are discussed. Since this experimental and evolving approach for the management of systemic amyloidosis is potentially applicable to a limited number of patients, multicenter collaboration may be needed to further define the infectious risks in this unique subset of transplant recipients.

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Fatal Disseminated Aspergillosis following Sequential Heart and Stem Cell Transplantation for Systemic Amyloidosis

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