Fatty acid amide hydrolase substrate specificity

Dale L. Boger, Robert A. Fecik, Jean E. Patterson, Hiroshi Miyauchi, Matthew P. Patricelli, Benjamin F. Cravatt

Research output: Contribution to journalArticlepeer-review

84 Scopus citations

Abstract

Fatty acid amide hydrolase (FAAH), also referred to as oleamide hydrolase and anandamide amidohydrolase, is a serine hydrolase responsible for the degradation of endogenous oleamide and anandamide, fatty acid amides that function as chemical messengers. FAAH hydrolyzes a range of fatty acid amides, and the present study examines the relative rates of hydrolysis of a variety of natural and unnatural fatty acid primary amide substrates using pure recombinant rat FAAH. (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)2613-2616
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume10
Issue number23
DOIs
StatePublished - Dec 4 2000

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