Feasibility Study of Catheter-Based Interventions for Anisotropic Expanded Polytetrafluoroethylene Cardiovascular Conduits in a Growing Lamb Model

Anthony Azakie, John P. Carney, Matthew T. Lahti, Melissa K. Seiberlich, Gurumurthy Hiremath, Yuriy Moklyak, Richard W. Bianco

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Cardiovascular repair in children often requires implant of conduits which do not have growth potential and will require reoperation. In the current study we sought to determine the feasibility of catheter-based interventions of anisotropic conduits inserted as interposition grafts in the main pulmonary artery (MPA) of growing lambs. Methods: Lambs underwent interpositional implant of either an anisotropic expanded polytetrafluoroethylene (ePTFE) (Test) conduit or conventional PTFE (Control) conduit. In the postoperative period, lambs were anesthetized and underwent catheter-based interventions consisting of hemodynamic and angiographic data collection, balloon dilation and/or stenting of the conduit at 3, 6 or 9 month postoperative time point. Results: At 3 months, control lambs showed significant increases in right ventricular pressures and trans-conduit gradients in comparison to test lambs. Test conduit diameters were significantly larger compared to controls due to spontaneous radial expansion of the anisotropic conduit. Balloon dilation of test conduits at 3 and 6 months showed a reduction in RV pressure and statistically significant improvement in the RV outflow tract gradient as well as significant increase in graft diameter, compared to both control and pre-dilation conditions. Furthermore, the test conduit diameter increased significantly compared to the pre-balloon and control conditions at each time point. Necropsy of test conduits showed no evidence of tears, perforations, or clot and smooth interiors with well-healed anastomoses. Conclusions: Anisotropic conduits implanted as interposition grafts in the MPA show spontaneous expansion, and can safely and effectively undergo catheter-based interventions, with significant increases in graft diameter occurring after balloon dilation.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalJournal of Investigative Surgery
DOIs
StatePublished - 2020

Bibliographical note

Publisher Copyright:
© 2020, © 2020 The Author(s). Published with license by Taylor and Francis Group, LLC.

Keywords

  • Growing lamb model
  • balloon dilation
  • cardiac surgery
  • conduits
  • congenital heart defects
  • valved stent

PubMed: MeSH publication types

  • Journal Article

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