Fecal hydrogen production and consumption measurements. Response to daily lactose ingestion by lactose maldigesters

Steven R. Hertzler; Dennis A. Savaiano; Michael D. Levitt

doi:10.1023/A:1018822103911

Fecal hydrogen production and consumption measurements. Response to daily lactose ingestion by lactose maldigesters

Steven R. Hertzler, Dennis A. Savaiano, Michael D. Levitt

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47 Scopus citations

Abstract

The alteration of hydrogen (H₂) metabolism, which accounts for the large decrease in breath H₂ excretion following prolonged ingestion of malabsorbed carbohydrate (lactulose, lactose in lactose maldigesters) was studied in six lactose-maldigesting adults. Metabolic inhibitors of the three main H₂-consuming reactions (methanogenesis, sulfate reduction, and acetogenesis) were used to independently measure H₂ production and consumption in fecal samples obtained after 10 days of either dextrose or lactose feeding. Absolute fecal H₂ production (net of production minus consumption) after 3 hr of incubation with lactose was approximately threefold lower after lactose adaptation (242 ± 54 μl) compared to dextrose adaptation (680 ± 79 μl, P = 0.006). Fecal H₂ consumption was not affected by either feeding period. We conclude that decreased absolute H₂ production, rather than increased H₂ consumption, is responsible for the decrease in breath H₂ observed with lactose feeding.

Original language	English (US)
Pages (from-to)	348-353
Number of pages	6
Journal	Digestive Diseases and Sciences
Volume	42
Issue number	2
DOIs	https://doi.org/10.1023/A:1018822103911
State	Published - 1997
Externally published	Yes

Bibliographical note

Funding Information:
Supported in part by the Department of Veterans Affairs, the National Institute of Diabetes and Digestive and Kidney Disease (RO1-DK-13309), and the University of Minnesota Agricultural Experiment Station (18-016).

Keywords

colonic adaptation
hydrogen production
lactose maldigestion

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title = "Fecal hydrogen production and consumption measurements. Response to daily lactose ingestion by lactose maldigesters",

abstract = "The alteration of hydrogen (H2) metabolism, which accounts for the large decrease in breath H2 excretion following prolonged ingestion of malabsorbed carbohydrate (lactulose, lactose in lactose maldigesters) was studied in six lactose-maldigesting adults. Metabolic inhibitors of the three main H2-consuming reactions (methanogenesis, sulfate reduction, and acetogenesis) were used to independently measure H2 production and consumption in fecal samples obtained after 10 days of either dextrose or lactose feeding. Absolute fecal H2 production (net of production minus consumption) after 3 hr of incubation with lactose was approximately threefold lower after lactose adaptation (242 ± 54 μl) compared to dextrose adaptation (680 ± 79 μl, P = 0.006). Fecal H2 consumption was not affected by either feeding period. We conclude that decreased absolute H2 production, rather than increased H2 consumption, is responsible for the decrease in breath H2 observed with lactose feeding.",

keywords = "colonic adaptation, hydrogen production, lactose maldigestion",

author = "Hertzler, {Steven R.} and Savaiano, {Dennis A.} and Levitt, {Michael D.}",

note = "Funding Information: Supported in part by the Department of Veterans Affairs, the National Institute of Diabetes and Digestive and Kidney Disease (RO1-DK-13309), and the University of Minnesota Agricultural Experiment Station (18-016).",

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AU - Hertzler, Steven R.

AU - Savaiano, Dennis A.

AU - Levitt, Michael D.

N1 - Funding Information: Supported in part by the Department of Veterans Affairs, the National Institute of Diabetes and Digestive and Kidney Disease (RO1-DK-13309), and the University of Minnesota Agricultural Experiment Station (18-016).

PY - 1997

Y1 - 1997

N2 - The alteration of hydrogen (H2) metabolism, which accounts for the large decrease in breath H2 excretion following prolonged ingestion of malabsorbed carbohydrate (lactulose, lactose in lactose maldigesters) was studied in six lactose-maldigesting adults. Metabolic inhibitors of the three main H2-consuming reactions (methanogenesis, sulfate reduction, and acetogenesis) were used to independently measure H2 production and consumption in fecal samples obtained after 10 days of either dextrose or lactose feeding. Absolute fecal H2 production (net of production minus consumption) after 3 hr of incubation with lactose was approximately threefold lower after lactose adaptation (242 ± 54 μl) compared to dextrose adaptation (680 ± 79 μl, P = 0.006). Fecal H2 consumption was not affected by either feeding period. We conclude that decreased absolute H2 production, rather than increased H2 consumption, is responsible for the decrease in breath H2 observed with lactose feeding.

AB - The alteration of hydrogen (H2) metabolism, which accounts for the large decrease in breath H2 excretion following prolonged ingestion of malabsorbed carbohydrate (lactulose, lactose in lactose maldigesters) was studied in six lactose-maldigesting adults. Metabolic inhibitors of the three main H2-consuming reactions (methanogenesis, sulfate reduction, and acetogenesis) were used to independently measure H2 production and consumption in fecal samples obtained after 10 days of either dextrose or lactose feeding. Absolute fecal H2 production (net of production minus consumption) after 3 hr of incubation with lactose was approximately threefold lower after lactose adaptation (242 ± 54 μl) compared to dextrose adaptation (680 ± 79 μl, P = 0.006). Fecal H2 consumption was not affected by either feeding period. We conclude that decreased absolute H2 production, rather than increased H2 consumption, is responsible for the decrease in breath H2 observed with lactose feeding.

KW - colonic adaptation

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KW - lactose maldigestion

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Fecal hydrogen production and consumption measurements. Response to daily lactose ingestion by lactose maldigesters

Abstract

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Keywords

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