Fe(III)-templated Gd(III) self-assemblies - A new route toward macromolecular MRI contrast agents

Valérie C. Pierre, Mauro Botta, Silvio Aime, Kenneth N. Raymond

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

The self-assembly of supramolcular clusters of Gd(III) hydroxypyridinone complexes, templated by an Fe(III) terephthalamide center, is presented. The peripheral Gd(III) ions are each coordinated by two water molecules which exchange rapidly with the bulk solvent. These properties, along with the high rigidity of the supramolecules, efficiently increase the rotational correlation times of the cluster, resulting in high relaxivities at high magnetic fields and hence making these complexes good candidates for MRI contrast agents.

Original languageEnglish (US)
Pages (from-to)9272-9273
Number of pages2
JournalJournal of the American Chemical Society
Volume128
Issue number29
DOIs
StatePublished - Jul 26 2006

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