Fe3O4 incorporated AOT-alginate nanoparticles for drug delivery

Chandran Sudakar; Ambesh Dixit; Rajesh Regmi; Ratna Naik; Gavin Lawes; Vaman M. Naik; Prem P. Vaishnava; Udaya Toti; Jayanth Panyam

doi:10.1109/TMAG.2008.2001324

Fe₃O₄ incorporated AOT-alginate nanoparticles for drug delivery

Chandran Sudakar, Ambesh Dixit, Rajesh Regmi, Ratna Naik, Gavin Lawes, Vaman M. Naik, Prem P. Vaishnava, Udaya Toti, Jayanth Panyam

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Composite nanoparticles of aerosol OT-alginate hydrogel loaded with Fe ₃O₄ and rhodamine 6G (R6G) in average diameter between 25 nm and 50 nm were synthesized by emulsification-cross-linking process and characterized by transmission electron microscopy (TEM) and SQUID magnetometery measurements. TEM measurements show that the Fe₃O₄ particles are uniformly distributed within AOT-alginate nanoparticles. The Ca²⁺ cross-linked AOT-alginate nanoparticles loaded with Fe ₃O₄ and rhodamine showed superparamagnetic behavior at room temperature with saturation magnetization of ∼50 emu/g of Fe ₃O₄. Similar behavior was exhibited by Fe²⁺ cross-linked AOT-alginate nanoparticles loaded with Fe₃O₄ and rhodamine except it showed twice the magnetization of Ca²⁺ crosslinked counterpart. A decrease in the amount of rhodamine loading for the composite nanoparticle systems as compared to the bare AOT-alginate nanoparticles was found.

Original language	English (US)
Pages (from-to)	2800-2803
Number of pages	4
Journal	IEEE Transactions on Magnetics
Volume	44
Issue number	11 PART 1
DOIs	https://doi.org/10.1109/TMAG.2008.2001324
State	Published - Nov 2008
Externally published	Yes

Keywords

Drug delivery
Magnetite
Polymer composite nanoparticles
Superparamagnetic properties

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title = "Fe3O4 incorporated AOT-alginate nanoparticles for drug delivery",

abstract = "Composite nanoparticles of aerosol OT-alginate hydrogel loaded with Fe 3O4 and rhodamine 6G (R6G) in average diameter between 25 nm and 50 nm were synthesized by emulsification-cross-linking process and characterized by transmission electron microscopy (TEM) and SQUID magnetometery measurements. TEM measurements show that the Fe3O4 particles are uniformly distributed within AOT-alginate nanoparticles. The Ca2+ cross-linked AOT-alginate nanoparticles loaded with Fe 3O4 and rhodamine showed superparamagnetic behavior at room temperature with saturation magnetization of ∼50 emu/g of Fe 3O4. Similar behavior was exhibited by Fe2+ cross-linked AOT-alginate nanoparticles loaded with Fe3O4 and rhodamine except it showed twice the magnetization of Ca2+ crosslinked counterpart. A decrease in the amount of rhodamine loading for the composite nanoparticle systems as compared to the bare AOT-alginate nanoparticles was found.",

keywords = "Drug delivery, Magnetite, Polymer composite nanoparticles, Superparamagnetic properties",

author = "Chandran Sudakar and Ambesh Dixit and Rajesh Regmi and Ratna Naik and Gavin Lawes and Naik, {Vaman M.} and Vaishnava, {Prem P.} and Udaya Toti and Jayanth Panyam",

year = "2008",

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AU - Sudakar, Chandran

AU - Dixit, Ambesh

AU - Regmi, Rajesh

AU - Naik, Ratna

AU - Lawes, Gavin

AU - Naik, Vaman M.

AU - Vaishnava, Prem P.

AU - Toti, Udaya

AU - Panyam, Jayanth

PY - 2008/11

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N2 - Composite nanoparticles of aerosol OT-alginate hydrogel loaded with Fe 3O4 and rhodamine 6G (R6G) in average diameter between 25 nm and 50 nm were synthesized by emulsification-cross-linking process and characterized by transmission electron microscopy (TEM) and SQUID magnetometery measurements. TEM measurements show that the Fe3O4 particles are uniformly distributed within AOT-alginate nanoparticles. The Ca2+ cross-linked AOT-alginate nanoparticles loaded with Fe 3O4 and rhodamine showed superparamagnetic behavior at room temperature with saturation magnetization of ∼50 emu/g of Fe 3O4. Similar behavior was exhibited by Fe2+ cross-linked AOT-alginate nanoparticles loaded with Fe3O4 and rhodamine except it showed twice the magnetization of Ca2+ crosslinked counterpart. A decrease in the amount of rhodamine loading for the composite nanoparticle systems as compared to the bare AOT-alginate nanoparticles was found.

AB - Composite nanoparticles of aerosol OT-alginate hydrogel loaded with Fe 3O4 and rhodamine 6G (R6G) in average diameter between 25 nm and 50 nm were synthesized by emulsification-cross-linking process and characterized by transmission electron microscopy (TEM) and SQUID magnetometery measurements. TEM measurements show that the Fe3O4 particles are uniformly distributed within AOT-alginate nanoparticles. The Ca2+ cross-linked AOT-alginate nanoparticles loaded with Fe 3O4 and rhodamine showed superparamagnetic behavior at room temperature with saturation magnetization of ∼50 emu/g of Fe 3O4. Similar behavior was exhibited by Fe2+ cross-linked AOT-alginate nanoparticles loaded with Fe3O4 and rhodamine except it showed twice the magnetization of Ca2+ crosslinked counterpart. A decrease in the amount of rhodamine loading for the composite nanoparticle systems as compared to the bare AOT-alginate nanoparticles was found.

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KW - Magnetite

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