TY - JOUR
T1 - Filling the holes in cystic kidney disease research
AU - Guay-Woodford, Lisa M.
AU - Henske, Elizabeth
AU - Igarashi, Peter
AU - Perrone, Ronald D.
AU - Reed-Gitomer, Berenice
AU - Somlo, Stefan
AU - Torres, Vicente E.
AU - Ketchum, Christian J.
AU - Star, Robert A.
AU - Flessner, Michael F.
AU - Rasooly, Rebekah S.
N1 - Publisher Copyright:
© 2014 by the American Society of Nephrology.
PY - 2014
Y1 - 2014
N2 - Kidney disease is a significant medical and public health problem. The National Institute of Diabetes and Digestive and Kidney Diseases recently asked the community to identify research objectives, which, if addressed, could improve understanding of basic kidney function and aid in prevention, treatment, and reversal of kidney disease. The Kidney Research National Dialogue invited interested parties to submit, discuss, and prioritize ideas using an interactive website; 1600 participants posted more than 300 ideas covering all areas of kidney disease, including the cystic kidney diseases. Although much is known about the genetics and pathogenesis of cystic diseases, there remain challenges to our understanding of the fundamentalmechanisms of cyst formation,what genes act as modifiers to cause variable responses in different people, and howto detect andmonitor disease progression. This article summarizes key research questions for cystic kidney diseases.
AB - Kidney disease is a significant medical and public health problem. The National Institute of Diabetes and Digestive and Kidney Diseases recently asked the community to identify research objectives, which, if addressed, could improve understanding of basic kidney function and aid in prevention, treatment, and reversal of kidney disease. The Kidney Research National Dialogue invited interested parties to submit, discuss, and prioritize ideas using an interactive website; 1600 participants posted more than 300 ideas covering all areas of kidney disease, including the cystic kidney diseases. Although much is known about the genetics and pathogenesis of cystic diseases, there remain challenges to our understanding of the fundamentalmechanisms of cyst formation,what genes act as modifiers to cause variable responses in different people, and howto detect andmonitor disease progression. This article summarizes key research questions for cystic kidney diseases.
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U2 - 10.2215/CJN.03410414
DO - 10.2215/CJN.03410414
M3 - Article
C2 - 24903391
AN - SCOPUS:84911438013
SN - 1555-9041
VL - 9
SP - 1799
EP - 1801
JO - Clinical Journal of the American Society of Nephrology
JF - Clinical Journal of the American Society of Nephrology
IS - 10
ER -