TY - JOUR
T1 - Finasteride in the treatment of men with frontal male pattern hair loss
AU - Leyden, J.
AU - Dunlap, F.
AU - Miller, B.
AU - Winters, P.
AU - Lebwohl, M.
AU - Hecker, D.
AU - Kraus, S.
AU - Baldwin, H.
AU - Shalita, A.
AU - Draelos, Z.
AU - Markou, M.
AU - Thiboutot, D.
AU - Rapaport, M.
AU - Kang, S.
AU - Kelly, T.
AU - Pariser, D.
AU - Webster, G.
AU - Hordinsky, M.
AU - Rietschel, R.
AU - Katz, H. I.
AU - Terranella, L.
AU - Best, S.
AU - Round, E.
AU - Waldstreicher, J.
PY - 1999
Y1 - 1999
N2 - Background: Finasteride, a specific inhibitor of type II 5α-reductase, decreases serum and scalp dihydrotestosterone and has been shown to be effective in men with vertex male pattern hair loss. Objective: This study evaluated the efficacy of finasteride 1 mg/day in men with frontal (anterior/mid) scalp hair thinning. Methods: This was a 1-year, double- blind, placebo-controlled study followed by a 1-year open extension. Efficacy was assessed by hair counts (1 cm2 circular area), patient and investigator assessments, and global photographic review. Results: There was a significant increase in hair count in the frontal scalp of finasteride-treated patients (P < .001), as well as significant improvements in patient, investigator, and global photographic assessments. Efficacy was maintained or improved throughout the second year of the study. Finasteride was generally well tolerated. Conclusion: In men with hair loss in the anterior/mid area of the scalp, finasteride 1 mg/day slowed hair loss and increased hair growth.
AB - Background: Finasteride, a specific inhibitor of type II 5α-reductase, decreases serum and scalp dihydrotestosterone and has been shown to be effective in men with vertex male pattern hair loss. Objective: This study evaluated the efficacy of finasteride 1 mg/day in men with frontal (anterior/mid) scalp hair thinning. Methods: This was a 1-year, double- blind, placebo-controlled study followed by a 1-year open extension. Efficacy was assessed by hair counts (1 cm2 circular area), patient and investigator assessments, and global photographic review. Results: There was a significant increase in hair count in the frontal scalp of finasteride-treated patients (P < .001), as well as significant improvements in patient, investigator, and global photographic assessments. Efficacy was maintained or improved throughout the second year of the study. Finasteride was generally well tolerated. Conclusion: In men with hair loss in the anterior/mid area of the scalp, finasteride 1 mg/day slowed hair loss and increased hair growth.
UR - http://www.scopus.com/inward/record.url?scp=0033067815&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033067815&partnerID=8YFLogxK
U2 - 10.1016/S0190-9622(99)70081-2
DO - 10.1016/S0190-9622(99)70081-2
M3 - Article
C2 - 10365924
AN - SCOPUS:0033067815
SN - 0190-9622
VL - 40
SP - 930
EP - 937
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 6 I
ER -