Comprehensive evidence-based guidelines for the practice of pancreas transplantation are yet to be established. The First World Consensus Conference on Pancreas Transplantation was convened for this purpose. A steering committee selected the participants and defined the questions to be addressed. A group of literature reviewers identified 597 studies to be included in summaries for guidelines production. Expert groups formulated the first draft of recommendations. Two rounds of discussion and voting occurred online, using the Delphi method (agreement rate ≥85%). After each round, critical responses of experts were reviewed, and recommendations were amended accordingly. Recommendations were finalized after live discussions. Each session was preceded by expert presentations and a summary of results of systematic literature review. Up to three voting rounds were allowed for each recommendation. To avoid potential conflicts of interest, deliberations on issues regarding the impact of pancreas transplantation on the management of diabetes were conducted by an independent jury. Recommendations on technical issues were determined by experts and validated using the Appraisal of Guidelines for Research and Evaluation (AGREE) II instrument. Quality of evidence was assessed using the Scottish Intercollegiate Guidelines Network (SIGN) methodology. Each recommendation received a GRADE rating (Grading of Recommendations, Assessment, Development and Evaluations).
Bibliographical noteFunding Information:
The First World Consensus Conference on Pancreas Transplantation was supported by the International Pancreas and Islet Transplant Association (IPITA) and was organized under the auspices of the European Society for Organ Transplantation, the European Association for the Study of Diabetes, the Italian Society for Organ Transplantation, The Italian Society of Surgery, the Italian Society of Diabetology, the Italian Association of Diabetologists, and the Italian Society of Endocrinology. The consensus conference was also endorsed by the Italian Prime Minister's Office, the Italian Ministry of Health, the Tuscany Region, and the City of Pisa.
The consensus conference received no funds from private companies. Costs were largely covered by a main unrestricted grant from Fondazione Pisa ( https://www.fondazionepisa.it/ ). Additional financial support was obtained from Tuscany Region, University of Pisa, and Pisa University Hospital. There was also an economic contribution from registration fees. Industries were not involved in any step of the consensus, and no representative of commercial companies was involved in any committee, jury, expert panel, or literature review groups. No participant received an honorarium. Travel expenses were covered by modest preset amounts based on the distance to travel to the meeting. Lodging expenses were covered for all participants.
This consensus conference is dedicated to the loved memory of Mr. Fabrizio Iacopini, who made most of the local arrangements for the live sessions and unexpectedly died of COVID-19 before these proceedings could be published. The First World Consensus Conference had no funding from commercial companies. The conference received a main unrestricted grant from Fondazione Pisa. The following institutions also provided additional financial support: Regione Toscana, Universit? di Pisa, and Azienda Ospedaliero Universitaria Pisana.
Another key feature of our consensus conference is that we did not receive any funding or support from any commercial company. The successful organization of a conference free of any potential commercial bias was made possible by a 2‐year fundraising effort to secure financial support from local institutions, mostly based on the commitment of local members of the steering committee. The degree of difficulty involved in bias‐free fundraising may have been among the reasons why this type of a consensus conference had never been held in the past.
© 2021 The Authors. American Journal of Transplantation published by Wiley Periodicals LLC on behalf of The American Society of Transplantation and the American Society of Transplant Surgeons
- clinical research / practice
- pancreas / simultaneous pancreas-kidney transplantation