Flow Cytometry to Assess Cerebrospinal Fluid Fungal Burden in Cryptococcal Meningitis

James E. Scriven; Lisa M. Graham; Charlotte Schutz; Thomas J. Scriba; Robert J. Wilkinson; David R. Boulware; Graeme Meintjes; David G. Lalloo; Britta C. Urban

doi:10.1128/JCM.03002-15

Flow Cytometry to Assess Cerebrospinal Fluid Fungal Burden in Cryptococcal Meningitis

James E. Scriven, Lisa M. Graham, Charlotte Schutz, Thomas J. Scriba, Robert J. Wilkinson, David R. Boulware, Graeme Meintjes, David G. Lalloo, Britta C. Urban

Medicine - Infectious Disease and International

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Abstract

Fungal burden in the cerebrospinal fluid is an important determinant of mortality in cryptococcal meningitis, but its use in aiding clinical decision making is hampered by the time involved to perform quantitative cultures. Here, we demonstrate the potential of flow cytometry as a novel and rapid technique to address this issue.

Original language	English (US)
Pages (from-to)	802-804
Number of pages	3
Journal	Journal of clinical microbiology
Volume	54
Issue number	3
DOIs	https://doi.org/10.1128/JCM.03002-15
State	Published - Mar 2016

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© 2016, American Society for Microbiology. All Rights Reserved.

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title = "Flow Cytometry to Assess Cerebrospinal Fluid Fungal Burden in Cryptococcal Meningitis",

abstract = "Fungal burden in the cerebrospinal fluid is an important determinant of mortality in cryptococcal meningitis, but its use in aiding clinical decision making is hampered by the time involved to perform quantitative cultures. Here, we demonstrate the potential of flow cytometry as a novel and rapid technique to address this issue.",

author = "Scriven, {James E.} and Graham, {Lisa M.} and Charlotte Schutz and Scriba, {Thomas J.} and Wilkinson, {Robert J.} and Boulware, {David R.} and Graeme Meintjes and Lalloo, {David G.} and Urban, {Britta C.}",

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AU - Scriven, James E.

AU - Graham, Lisa M.

AU - Schutz, Charlotte

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AU - Wilkinson, Robert J.

AU - Boulware, David R.

AU - Meintjes, Graeme

AU - Lalloo, David G.

AU - Urban, Britta C.

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AB - Fungal burden in the cerebrospinal fluid is an important determinant of mortality in cryptococcal meningitis, but its use in aiding clinical decision making is hampered by the time involved to perform quantitative cultures. Here, we demonstrate the potential of flow cytometry as a novel and rapid technique to address this issue.

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Flow Cytometry to Assess Cerebrospinal Fluid Fungal Burden in Cryptococcal Meningitis

Abstract

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