TY - JOUR
T1 - Flow-rate dependence of post-column reaction chromatographic detectors and optimization of reactor length for slow chemical reactions
AU - Shih, Y. T.
AU - Carr, Peter W.
PY - 1985
Y1 - 1985
N2 - In high-performance liquid chromatography, use of any post-column reactor invariably involves a compromise between the conditions needed to obtain complete reaction and avoidance of excessive dispersion by band broadening in the reactor. Flow rate and the reactor geometry interact to establish the final chromatographic performance. Based on the flow-rate dependence of the peak area and peak height, post-column detectors constitute a distinct class of detectors which differ from mass-flow and concentrations-sensitive detectors such as the flame ionization and absorbance detector, respectively. The concept of reactor length optimization is developed for first-order chemical reactions in a post-column detector. The findings are applicable to both chromatographic and flow-injection systems.
AB - In high-performance liquid chromatography, use of any post-column reactor invariably involves a compromise between the conditions needed to obtain complete reaction and avoidance of excessive dispersion by band broadening in the reactor. Flow rate and the reactor geometry interact to establish the final chromatographic performance. Based on the flow-rate dependence of the peak area and peak height, post-column detectors constitute a distinct class of detectors which differ from mass-flow and concentrations-sensitive detectors such as the flame ionization and absorbance detector, respectively. The concept of reactor length optimization is developed for first-order chemical reactions in a post-column detector. The findings are applicable to both chromatographic and flow-injection systems.
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U2 - 10.1016/S0003-2670(00)84416-5
DO - 10.1016/S0003-2670(00)84416-5
M3 - Article
AN - SCOPUS:0343159393
SN - 0003-2670
VL - 167
SP - 137
EP - 144
JO - Analytica Chimica Acta
JF - Analytica Chimica Acta
IS - C
ER -