Force assessment in periodic paralysis after electrical muscle stimulation

John W. Day, Carl Sakamoto, Gareth J Parry, Frank Lehmann-Horn, Paul A Iaizzo

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Objective: To obtain an objective measure of muscle force in periodic paralysis, we studied ankle dorsiflexion torque during induced paralytic attacks in hyperkalemic and hypokalemic patients. Subjects, Patients, and Methods: Dorsiflexor torque after peroneal nerve stimulation was recorded during provocative tests on 5 patients with hypokalemic or hyperkalemic disorders and on 2 control subjects (1995-2001). Manual strength assessment was simultaneously performed in a blinded fashion. Standardized provocation procedures were used. Results: The loss of torque in hyperkalemic patients roughly paralleled the loss of clinically detectable strength, whereas in the hypokalemic patients, pronounced torque loss occurred well before observed clinical effects. No dramatic changes occurred in the control subjects. Torque amplitude decreased more than 70% in all patients during the provocation tests; such decreases were associated with alterations induced in serum potassium concentrations. Conclusions: Stimulated torque measurement offers several advantages in characterizing muscle dysfunction in periodic paralysis: (1) it is independent of patient effort; (2) it can show a definitely abnormal response early during provocative maneuvers; and (3) characteristics of muscle contraction can be measured that are unobservable during voluntary contraction. Stimulated torque measurements can characterize phenotypic muscle function in neuromuscular diseases.

Original languageEnglish (US)
Pages (from-to)232-240
Number of pages9
JournalMayo Clinic Proceedings
Volume77
Issue number3
DOIs
StatePublished - Mar 2002

Bibliographical note

Funding Information:
Financial support provided by the University of Minnesota Graduate School and the Center for Muscle and Muscle Disorders at the University of Minnesota, Minneapolis.

Keywords

  • CMAP = compound muscle action potential
  • ECG = electrocardiogram

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