Forensic style analysis with survival trajectories

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Scopus citations

Abstract

Electronic Health Records (EHRs) consists of patient information such as demographics, medications, laboratory test results, diagnosis codes and procedures. Mining EHRs could lead to improvement in patient healthcare management as EHRs contain detailed information related to disease prognosis for large patient populations. We hypothesize that a patient's condition does not deteriorate at random, the trajectories, sequences in which diseases appear in a patient, are determined by a finite number of underlying disease mechanisms. In this work, we exploit this idea by predicting a patient's risk of mortality in the context of the metabolic syndrome by assessing which of many available trajectories a patient is following and progression along this trajectory. Implementing this idea required innovative enhancements both for the study design and also for the fitting algorithm. We propose a forensic-style study design, which aligns patients on last follow-up and measures time backwards. We modify the time-dependent covariate Cox proportional hazards model to better capture coefficients of covariate that follow a particular temporal sequence, such as trajectories. Knowledge extracted from such analysis can lead to personalized treatments, thereby forming the basis for future trajectory-centered guidelines.

Original languageEnglish (US)
Title of host publicationProceedings - 15th IEEE International Conference on Data Mining, ICDM 2015
EditorsCharu Aggarwal, Zhi-Hua Zhou, Alexander Tuzhilin, Hui Xiong, Xindong Wu
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1069-1074
Number of pages6
ISBN (Electronic)9781467395038
DOIs
StatePublished - Jan 5 2016
Event15th IEEE International Conference on Data Mining, ICDM 2015 - Atlantic City, United States
Duration: Nov 14 2015Nov 17 2015

Publication series

NameProceedings - IEEE International Conference on Data Mining, ICDM
Volume2016-January
ISSN (Print)1550-4786

Other

Other15th IEEE International Conference on Data Mining, ICDM 2015
Country/TerritoryUnited States
CityAtlantic City
Period11/14/1511/17/15

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