Abstract
A formal synthesis of 7-methoxymitosene is achieved via a key platinum-catalyzed cycloisomerization. The precursor for the Pt catalysis, a fully functionalized benzene intermediate, was prepared via a regioselective electrophilic bromination followed by a chemoselective Sonogashira cross-coupling. It underwent the PtCl2-catalyzed cycloisomerization smoothly despite its hindered and highly electron-rich nature. Analogs of 7-methoxymitosene can be accessed in an expedient manner by following a similar synthetic sequence.
Original language | English (US) |
---|---|
Pages (from-to) | 3736-3739 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 14 |
Issue number | 14 |
DOIs | |
State | Published - Jul 20 2012 |
Externally published | Yes |