TY - JOUR
T1 - Formation of block copolymer-protected nanoparticles via reactive impingement mixing
AU - Zhu, Zhengxi
AU - Anacker, Jessica L.
AU - Ji, Shengxiang
AU - Hoye, Thomas R.
AU - Macosko, Christopher W.
AU - Prudhomme, Robert K.
PY - 2007/10/9
Y1 - 2007/10/9
N2 - Reactive impingement mixing was employed to produce polymer-protected nanoparticles. Amphiphilic block copolymer was formed in situ by reactive coupling of hydrophobic and hydrophilic blocks. Simultaneously, a hydrophobic compound and the copolymer coprecipitated to form nanoparticles in the range of 100 nm. Specifically, β-carotene was stabilized by the amphiphilic diblock copolymer, formed from the reaction of an amino-terminated hydrophilic block, polyethylene glycol) (PEG-NH 2), with an acid chloride-terminated hydrophobic block, either poly (ε-caprolactone) (PCL-COCl) or polystyrene (PS-COCl). Spherical particles were observed by scanning and cryogenic transmission electron microscopy. Process conditions, including feed concentration of β-carotene and feed concentrations of polymeric stabilizers, had little or no effect on average particle sizes over the range studied. Further, for Reynolds numbers greater than 500 the feed flow rates also had no effect. The effect of glass transition temperature (T g) of the hydrophobic polymer on morphology and particle formation mechanism is discussed.
AB - Reactive impingement mixing was employed to produce polymer-protected nanoparticles. Amphiphilic block copolymer was formed in situ by reactive coupling of hydrophobic and hydrophilic blocks. Simultaneously, a hydrophobic compound and the copolymer coprecipitated to form nanoparticles in the range of 100 nm. Specifically, β-carotene was stabilized by the amphiphilic diblock copolymer, formed from the reaction of an amino-terminated hydrophilic block, polyethylene glycol) (PEG-NH 2), with an acid chloride-terminated hydrophobic block, either poly (ε-caprolactone) (PCL-COCl) or polystyrene (PS-COCl). Spherical particles were observed by scanning and cryogenic transmission electron microscopy. Process conditions, including feed concentration of β-carotene and feed concentrations of polymeric stabilizers, had little or no effect on average particle sizes over the range studied. Further, for Reynolds numbers greater than 500 the feed flow rates also had no effect. The effect of glass transition temperature (T g) of the hydrophobic polymer on morphology and particle formation mechanism is discussed.
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U2 - 10.1021/la701420z
DO - 10.1021/la701420z
M3 - Article
C2 - 17824626
AN - SCOPUS:35448947165
SN - 0743-7463
VL - 23
SP - 10499
EP - 10504
JO - Langmuir
JF - Langmuir
IS - 21
ER -