Formation of tethered supported bilayers by vesicle fusion onto lipopolymer monolayers promoted by osmotic stress

Markus Seitz, Evgeny Ter-Ovanesyan, Marcus Hausch, Chad K. Park, Joseph A. Zasadzinski, Rudolf Zentel, Jacob N. Israelachvili

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

An evidence of tethered lipid bilayer formation by vesicle adsorption onto lipopolymer monolayers is studied using atomic force microscopy (AFM). Polymer hydration is found to be an important factor governing this process. It is found that hypotonic osmotic stress acting upon lipid vesicles stimulates their incorporation in homogeneous bilayers on polymeric substrates. The formation of multilamellar and more complex surface aggregates is prevented. The polymer-supported lipid membrane is indeed a thermodynamically stable structure which can self-organize after lipid is supplied to a polymer-supported monolayer in hydrophilic and saline environment.

Original languageEnglish (US)
Pages (from-to)6067-6070
Number of pages4
JournalLangmuir
Volume16
Issue number14
DOIs
StatePublished - Jul 11 2000

Fingerprint Dive into the research topics of 'Formation of tethered supported bilayers by vesicle fusion onto lipopolymer monolayers promoted by osmotic stress'. Together they form a unique fingerprint.

Cite this