TY - JOUR
T1 - FOXO1
T2 - A potential target for human diseases
AU - Lu, Huarui
AU - Huang, Haojie
PY - 2011/8
Y1 - 2011/8
N2 - The forkhead box O (FoxO) transcription factors are known to be involved in many physiological and pathological processes including apoptosis, cell cycle arrest, stress resistance, glucose metabolism, cellular differentiation and development, and tumor suppression. The environmental cues, such as growth factors, nutrients, oxidative stress and irradiation, can either positively or negatively modulate FoxO proteins' activities, thereby ensuring distinctive transcription programs in the cell. The potent activities of FoxOs are tightly controlled by multiple mechanisms, which include posttranslational modification such as phosphorylation, acetylation, methylation and ubiquitination, subcellular localization, and direct protein-protein interaction. Mounting evidence suggests that the human FOXO1 protein, a founding member of the FoxO family is likely involved in carcinogenesis, diabetes and other human diseases. Here we give an overview of most recent findings regarding the regulation and function of FoxO1, its potential role in human diseases and useful animal models for functional studies on FoxO1. Prospective ways in which the discoveries from the basic research of FoxO1 can be utilized for drug targeting and development of novel therapeutics for human diseases are also discussed.
AB - The forkhead box O (FoxO) transcription factors are known to be involved in many physiological and pathological processes including apoptosis, cell cycle arrest, stress resistance, glucose metabolism, cellular differentiation and development, and tumor suppression. The environmental cues, such as growth factors, nutrients, oxidative stress and irradiation, can either positively or negatively modulate FoxO proteins' activities, thereby ensuring distinctive transcription programs in the cell. The potent activities of FoxOs are tightly controlled by multiple mechanisms, which include posttranslational modification such as phosphorylation, acetylation, methylation and ubiquitination, subcellular localization, and direct protein-protein interaction. Mounting evidence suggests that the human FOXO1 protein, a founding member of the FoxO family is likely involved in carcinogenesis, diabetes and other human diseases. Here we give an overview of most recent findings regarding the regulation and function of FoxO1, its potential role in human diseases and useful animal models for functional studies on FoxO1. Prospective ways in which the discoveries from the basic research of FoxO1 can be utilized for drug targeting and development of novel therapeutics for human diseases are also discussed.
KW - Apoptosis
KW - Cancer
KW - Diabetes
KW - Foxo transcription factors
KW - Glucose metabolism
KW - Muscle atrophy
KW - Posttranslational modification
KW - The cell cycle
UR - http://www.scopus.com/inward/record.url?scp=79960023653&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79960023653&partnerID=8YFLogxK
U2 - 10.2174/138945011796150280
DO - 10.2174/138945011796150280
M3 - Article
C2 - 21443466
AN - SCOPUS:79960023653
SN - 1389-4501
VL - 12
SP - 1235
EP - 1244
JO - Current Drug Targets
JF - Current Drug Targets
IS - 9
ER -