Fragile X Tremor/Ataxia Syndrome: Blame the Messenger!

Maurice S. Swanson; Harry T. Orr

doi:10.1016/j.neuron.2007.07.032

Fragile X Tremor/Ataxia Syndrome: Blame the Messenger!

Maurice S. Swanson, Harry T. Orr

Laboratory Medicine and Pathology

Research output: Contribution to journal › Short survey › peer-review

15 Scopus citations

Abstract

rCGG repeats in premutant alleles of the fragile X gene (FMR1) cause neurodegeneration in Drosophila and are thought to cause fragile X-associated tremor/ataxia syndrome in humans. Two reports in this issue of Neuron (Jin et al. and Sofola et al.) present data indicating a disease mechanism involving disruption of RNA-binding protein function.

Original language	English (US)
Pages (from-to)	535-537
Number of pages	3
Journal	Neuron
Volume	55
Issue number	4
DOIs	https://doi.org/10.1016/j.neuron.2007.07.032
State	Published - Aug 16 2007

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title = "Fragile X Tremor/Ataxia Syndrome: Blame the Messenger!",

abstract = "rCGG repeats in premutant alleles of the fragile X gene (FMR1) cause neurodegeneration in Drosophila and are thought to cause fragile X-associated tremor/ataxia syndrome in humans. Two reports in this issue of Neuron (Jin et al. and Sofola et al.) present data indicating a disease mechanism involving disruption of RNA-binding protein function.",

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AB - rCGG repeats in premutant alleles of the fragile X gene (FMR1) cause neurodegeneration in Drosophila and are thought to cause fragile X-associated tremor/ataxia syndrome in humans. Two reports in this issue of Neuron (Jin et al. and Sofola et al.) present data indicating a disease mechanism involving disruption of RNA-binding protein function.

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Fragile X Tremor/Ataxia Syndrome: Blame the Messenger!

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