Free thyroxine levels in critically ill patients. A comparison of currently available assays

M. F. Slag; J. E. Morley; M. K. Elson; K. R. Labrosse; T. W. Crowson; frank q Nuttall; R. B. Shafer

doi:10.1001/jama.246.23.2702

Free thyroxine levels in critically ill patients. A comparison of currently available assays

M. F. Slag, J. E. Morley, M. K. Elson, K. R. Labrosse, T. W. Crowson, frank q Nuttall, R. B. Shafer

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31 Scopus citations

Abstract

Two indices of free thyroxin (T₄) and four methods of free T₄ measurement were compared in 85 patients with acute illness, hospitalized in intensive care units. All of the methods of free T₄ measurement in critical illness were nonspecific, and two of the methods failed to suggest hypothyroidism in two patients with primary hypothyroidism and another associated critical illness. Since the ideal screening test should be both sensitive and specific, all tests for free T₄ used in this study should be interpreted with caution in severely ill patients.

Original language	English (US)
Pages (from-to)	2702-2706
Number of pages	5
Journal	Journal of the American Medical Association
Volume	246
Issue number	23
DOIs	https://doi.org/10.1001/jama.246.23.2702
State	Published - Dec 1 1981
Externally published	Yes

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AU - Crowson, T. W.

AU - Nuttall, frank q

AU - Shafer, R. B.

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AB - Two indices of free thyroxin (T4) and four methods of free T4 measurement were compared in 85 patients with acute illness, hospitalized in intensive care units. All of the methods of free T4 measurement in critical illness were nonspecific, and two of the methods failed to suggest hypothyroidism in two patients with primary hypothyroidism and another associated critical illness. Since the ideal screening test should be both sensitive and specific, all tests for free T4 used in this study should be interpreted with caution in severely ill patients.

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Free thyroxine levels in critically ill patients. A comparison of currently available assays

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