Abstract
Delivery of therapeutics to the brain is challenging because of efflux pumps located in the vascular endothelium. A detailed analysis of Wnt signaling in a human brain endothelial cell line indicates that expression and function of P-glycoprotein, a major efflux transporter, is controlled by non-canonical Wnt signaling. Inhibition of this pathway leads to downregulation of P-glycoprotein and increased transcellular drug transport and reveals a potential strategy for improving drug delivery for treatment of neurologic diseases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1257 |
| Number of pages | 1 |
| Journal | Journal of Cerebral Blood Flow and Metabolism |
| Volume | 34 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2014 |
Keywords
- P-glycoprotein
- Wnt signaling
- blood-brain transport
- drug delivery
- neurovascular unit
- transporter
