From child maltreatment to emerging adult problem drinking: Identification of a multilevel internalizing pathway among African American youth

Elizabeth D. Handley, Fred A. Rogosch, Dante Cicchetti

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The present study tested the role of FKBP5 binding protein 5 (FKBP5) genetic variation in an internalizing pathway from child maltreatment to emerging adult problem drinking among a sample of African American youth (N = 280) followed prospectively from ages 11 to 20. Specifically, whether childhood internalizing symptoms and emerging adult tension reduction alcohol expectancies sequentially mediate the effect of child maltreatment on emerging adult problem drinking and whether FKBP5 moderates these associations were investigated. The results indicate that individuals with at least one copy of the FKBP5 CATT haplotype (minor alleles) are more vulnerable to traversing the hypothesized internalizing pathway of risk than individuals without this genotypic profile. Taken together our findings highlight the importance of FKBP5 genetic variation in the context of early adversity; support the role of two prospective sequential mediators of an internalizing pathway to problematic drinking, namely, childhood internalizing symptoms and emerging adult tension reduction alcohol expectancies; and identify a subgroup of maltreated children most susceptible to progressing along this less common pathway of risk.

Original languageEnglish (US)
Pages (from-to)1807-1821
Number of pages15
JournalDevelopment and psychopathology
Volume29
Issue number5
DOIs
StatePublished - Dec 1 2017

Bibliographical note

Funding Information:
We are grateful to the Jacobs Foundation (to D.C.) and the National Institute on Drug Abuse (R01-DA01774 to F.A.R. and D.C.) for their support of this work.

Publisher Copyright:
Copyright © Cambridge University Press 2017.

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