TY - JOUR
T1 - Frontal white matter microstructure and treatment response of late-life depression
T2 - A preliminary study
AU - Alexopoulos, George S.
AU - Kiosses, Dimitris N.
AU - Choi, Steven J.
AU - Murphy, Christopher F.
AU - Lim, Kelvin O.
PY - 2002/11/1
Y1 - 2002/11/1
N2 - Objective: This study tested the hypothesis that microstructural abnormalities in white matter areas of the brain containing frontostriatal tracts are associated with a low rate of remission of geriatric depression. Method: Thirteen older patients with major depression received open, but controlled, treatment with citalopram at a target daily dose of 40 mg for 12 weeks. Diffusion tensor imaging was used to determine fractional anisotropy in preselected white matter regions. Results: Survival analysis with Cox's proportional hazards model revealed that lower fractional anisotropy of the right and the left frontal white matter regions 15 mm above the anterior commissure-posterior commissure plane was associated with a low remission rate after age was considered. Remission was not significantly associated with fractional anisotropy of lower frontal regions or a temporal region. Conclusions: Microstructural white matter abnormalities lateral to the anterior cingulate may be associated with a low rate of remission of geriatric depression.
AB - Objective: This study tested the hypothesis that microstructural abnormalities in white matter areas of the brain containing frontostriatal tracts are associated with a low rate of remission of geriatric depression. Method: Thirteen older patients with major depression received open, but controlled, treatment with citalopram at a target daily dose of 40 mg for 12 weeks. Diffusion tensor imaging was used to determine fractional anisotropy in preselected white matter regions. Results: Survival analysis with Cox's proportional hazards model revealed that lower fractional anisotropy of the right and the left frontal white matter regions 15 mm above the anterior commissure-posterior commissure plane was associated with a low remission rate after age was considered. Remission was not significantly associated with fractional anisotropy of lower frontal regions or a temporal region. Conclusions: Microstructural white matter abnormalities lateral to the anterior cingulate may be associated with a low rate of remission of geriatric depression.
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U2 - 10.1176/appi.ajp.159.11.1929
DO - 10.1176/appi.ajp.159.11.1929
M3 - Article
C2 - 12411231
AN - SCOPUS:0036842532
SN - 0002-953X
VL - 159
SP - 1929
EP - 1932
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
IS - 11
ER -