TY - JOUR
T1 - Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits
AU - Miyazaki, Tadaaki
AU - Kawahara, Atsuo
AU - Fujii, Hodaka
AU - Nakagawa, Yoko
AU - Minami, Yasuhiro
AU - Liu, Zhao Jun
AU - Oishi, Isao
AU - Silvennoinen, Olli
AU - Witthuhn, Bruce A.
AU - Ihle, James N.
AU - Taniguchi, Tadatsugu
PY - 1994
Y1 - 1994
N2 - The interleukin-2 receptor (IL-2R) consists of three subunits: the IL-2Rα, IL-2Rβ, and IL-2Rγ chains, the last of which is also used in the receptors for IL-4, IL-7, and IL-9. Stimulation with IL-2 induces the tyrosine phosphorylation and activation of the Janus kinases Jak1 and Jak3. Jak1 and Jak3 were found to be selectively associated with the "serine-rich" region of IL-2Rβ and the carboxyl-terminal region of IL-2Rγ, respectively. Both regions were necessary for IL-2 signaling. Furthermore, Jak3-negative fibroblasts expressing reconstituted IL-2R became responsive to IL-2 after the additional expression of Jak3 complementary DNA. Thus, activation of Jak1 and Jak3 may be a key event in IL-2 signaling.
AB - The interleukin-2 receptor (IL-2R) consists of three subunits: the IL-2Rα, IL-2Rβ, and IL-2Rγ chains, the last of which is also used in the receptors for IL-4, IL-7, and IL-9. Stimulation with IL-2 induces the tyrosine phosphorylation and activation of the Janus kinases Jak1 and Jak3. Jak1 and Jak3 were found to be selectively associated with the "serine-rich" region of IL-2Rβ and the carboxyl-terminal region of IL-2Rγ, respectively. Both regions were necessary for IL-2 signaling. Furthermore, Jak3-negative fibroblasts expressing reconstituted IL-2R became responsive to IL-2 after the additional expression of Jak3 complementary DNA. Thus, activation of Jak1 and Jak3 may be a key event in IL-2 signaling.
UR - http://www.scopus.com/inward/record.url?scp=0027993022&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027993022&partnerID=8YFLogxK
U2 - 10.1126/science.7973659
DO - 10.1126/science.7973659
M3 - Article
C2 - 7973659
AN - SCOPUS:0027993022
SN - 0036-8075
VL - 266
SP - 1045
EP - 1047
JO - Science
JF - Science
IS - 5187
ER -