Functional MRI in mice lacking IP3-dependent calcium signaling in astrocytes

Pierrick Jego, Jesús Pacheco-Torres, Alfonso Araque, Santiago Canals

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Functional magnetic resonance imaging (fMRI) is a fundamental tool to investigate human brain networks. However, the cellular mechanisms underlying fMRI signals are not fully understood. One hypothetical mechanism is the putative vascular control exerted by cytosolic calcium in perivascular astrocytes. We have performed combined fMRI-electrophysiology experiments in mice lacking the inositol 1,4,5-triphosphate-type-2 receptor, with the primary pathway of cytosolic calcium increase eliminated into astrocytes. Our results show that evoked electrophysiologic activity and fMRI signals acquired during either transient or sustained neuronal activations occur independently of these large calcium signals. This result challenges the suggested intermediary role of astrocytic calcium surges in fMRI-signal generation.

Original languageEnglish (US)
Pages (from-to)1599-1603
Number of pages5
JournalJournal of Cerebral Blood Flow and Metabolism
Volume34
Issue number10
DOIs
StatePublished - Oct 1 2014

Keywords

  • BOLD
  • IP
  • astrocytes
  • calcium
  • fMRI
  • local field potentials

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